ID   HIS7_ZYGRC              Reviewed;         226 AA.
AC   Q9UVE1; C5DY77;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=HIS3; OrderedLocusNames=ZYRO0F10890g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10806420;
RX   DOI=10.1002/(sici)1097-0061(200005)16:7<581::aid-yea545>3.0.co;2-4;
RA   Sychrova H., Braun V., Souciet J.-L.;
RT   "Sequence and organization analyses of a Zygosaccharomyces rouxii DNA
RT   fragment containing the HIS3 gene.";
RL   Yeast 16:581-587(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; Y18561; CAB62291.1; -; Genomic_DNA.
DR   EMBL; CU928178; CAR28738.1; -; Genomic_DNA.
DR   RefSeq; XP_002497671.1; XM_002497626.1.
DR   AlphaFoldDB; Q9UVE1; -.
DR   SMR; Q9UVE1; -.
DR   STRING; 559307.Q9UVE1; -.
DR   EnsemblFungi; CAR28738; CAR28738; ZYRO0F10890g.
DR   GeneID; 8205437; -.
DR   KEGG; zro:ZYRO0F10890g; -.
DR   HOGENOM; CLU_044308_3_0_1; -.
DR   InParanoid; Q9UVE1; -.
DR   UniPathway; UPA00031; UER00011.
DR   Proteomes; UP000008536; Chromosome F.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158252"
FT   CONFLICT        50
FT                   /note="A -> R (in Ref. 1; CAB62291)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   226 AA;  24613 MW;  28A91DC1A87BD513 CRC64;
     MIPEQGEHKA FVQRNTNETK IQIAISLNGG HIEIPESIIG KKRVESDGVA TQATSSQTID
     IHTGVGFLDH MIHALAKHSG WSLIVECIGD LHIDDHHTTE DCGIALGDAF KQALGQVRGV
     KRFGFGFAPL DEALSRAVVD LSNRPYSVIE LGLKREKIGD LSCEMIPHFL ESFTEAARLT
     VHVDCLRGFN DHHRSESAFK ALAVALREAT SPNGTNDVPS TKGVLM