ID   3SOC1_MICCO             Reviewed;          78 AA.
AC   Q9PUB7;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Alpha-neurotoxin homolog 1;
DE            Short=NXH1;
DE   Flags: Precursor;
OS   Micrurus corallinus (Brazilian coral snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=54390;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Ho P.L., Soares M.B., Yamane T., Raw I.;
RT   "Reverse biology applied to Micrurus corallinus, a South American coral
RT   snake.";
RL   J. Toxicol. Toxin Rev. 14:327-337(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=10673386; DOI=10.1006/bbrc.1999.2033;
RA   Silveira de Oliveira J., Rossan de Brandao Prieto da Silva A., Soares M.B.,
RA   Stephano M.A., de Oliveira Dias W., Raw I., Ho P.L.;
RT   "Cloning and characterization of an alpha-neurotoxin-type protein specific
RT   for the coral snake Micrurus corallinus.";
RL   Biochem. Biophys. Res. Commun. 267:887-891(2000).
RN   [3]
RP   PROTEIN SEQUENCE OF 22-36, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=21515432; DOI=10.1016/j.jprot.2011.04.003;
RA   Correa-Netto C., Junqueira-de-Azevedo Ide L., Silva D.A., Ho P.L.,
RA   Leitao-de-Araujo M., Alves M.L., Sanz L., Foguel D., Zingali R.B.,
RA   Calvete J.J.;
RT   "Snake venomics and venom gland transcriptomic analysis of Brazilian coral
RT   snakes, Micrurus altirostris and M. corallinus.";
RL   J. Proteomics 74:1795-1809(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21515432}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group XII sub-subfamily. {ECO:0000305}.
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DR   EMBL; AF197563; AAF13250.1; -; mRNA.
DR   AlphaFoldDB; Q9PUB7; -.
DR   SMR; Q9PUB7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:21515432"
FT   CHAIN           22..78
FT                   /note="Alpha-neurotoxin homolog 1"
FT                   /evidence="ECO:0000305|PubMed:21515432"
FT                   /id="PRO_0000035449"
FT   DISULFID        24..42
FT                   /evidence="ECO:0000250|UniProtKB:P01414"
FT   DISULFID        37..57
FT                   /evidence="ECO:0000250|UniProtKB:P01414"
FT   DISULFID        59..70
FT                   /evidence="ECO:0000250|UniProtKB:P01414"
FT   DISULFID        71..76
FT                   /evidence="ECO:0000250|UniProtKB:P01414"
SQ   SEQUENCE   78 AA;  8572 MW;  70FA5B550B77D184 CRC64;
     MKTLLLTLVV VTIVCLDFGY TIVCYKRHAS DSQTTTCLSG ICYKKITRGI SRPEMGCGCP
     QSSRGVKVEC CMRDKCNG