ID   ANR_EISFE               Reviewed;         420 AA.
AC   Q75W84;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Annetocin receptor;
GN   Name=anr {ECO:0000312|EMBL:BAD15088.1};
OS   Eisenia fetida (Red wiggler worm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Oligochaeta; Crassiclitellata; Lumbricina; Lumbricidae; Lumbricinae;
OC   Eisenia.
OX   NCBI_TaxID=6396;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAD15088.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=15175002; DOI=10.1042/bj20040555;
RA   Kawada T., Kanda A., Minakata H., Matsushima O., Satake H.;
RT   "Identification of a novel receptor for an invertebrate
RT   oxytocin/vasopressin superfamily peptide: molecular and functional
RT   evolution of the oxytocin/vasopressin superfamily.";
RL   Biochem. J. 382:231-237(2004).
CC   -!- FUNCTION: Receptor for annetocin. Activation by annetocin may induce
CC       egg-laying behavior through calcium-dependent signaling.
CC       {ECO:0000269|PubMed:15175002}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Nephridia in clitellum region.
CC       {ECO:0000269|PubMed:15175002}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
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DR   EMBL; AB121771; BAD15088.1; -; mRNA.
DR   AlphaFoldDB; Q75W84; -.
DR   SMR; Q75W84; -.
DR   GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016500; F:protein-hormone receptor activity; IDA:UniProtKB.
DR   GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IC:UniProtKB.
DR   GO; GO:0018991; P:oviposition; TAS:UniProtKB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..420
FT                   /note="Annetocin receptor"
FT                   /id="PRO_0000069172"
FT   TOPO_DOM        1..54
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..124
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..166
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        350..360
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        382..420
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          397..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        22
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        122..201
FT                   /evidence="ECO:0000250|UniProtKB:P02699,
FT                   ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   420 AA;  46410 MW;  AC6A8B8114BC9275 CRC64;
     MEMDDDEAIL LDDIYALAST PNQTIVTSSF PQTVSPGFLA RRNEALAMVE VAVQSTILIL
     TVVGNAAVLA MIVSLSRHKD LGRMYTMIGH LSCADLFVAI FNLLPQLLWD VTHRFRGGRV
     LCKLVKYVQV VAMYASAYVL MSTAVDRYTA ICHPMRSHTW TSTTAHYLVI GAWVLALVFA
     VPQLVIFDYV EVVPGSGVYD CVDHFRPRWT LPVYITWFAL AVYVIPLVVL ATIYLRICVV
     VWKSANRKST PMINVAARTS GATEQPSLDD ASVSFNVADG GGVDLDPSGG GGSLSRHAAQ
     LSHRQQQQQA NNVVLSRAKT KTVKLTLTVV ISYLVCWAPF FVSHIWSAWD PHAPFEGTEM
     VITLLLGSLN SCINPWIYLA FSDQLRRKVT QCCPRSWGQR PSTLSHDSTD FRSGSRPTHS