HIS82_PASMU
ID HIS82_PASMU Reviewed; 365 AA.
AC Q9CMI7;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Histidinol-phosphate aminotransferase 2;
DE EC=2.6.1.9;
DE AltName: Full=Imidazole acetol-phosphate transaminase 2;
GN Name=hisC2; Synonyms=hisH_1; OrderedLocusNames=PM0838;
OS Pasteurella multocida (strain Pm70).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Pasteurella.
OX NCBI_TaxID=272843;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pm70;
RX PubMed=11248100; DOI=10.1073/pnas.051634598;
RA May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT "Complete genomic sequence of Pasteurella multocida Pm70.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-
CC oxopropyl phosphate + L-glutamate; Xref=Rhea:RHEA:23744,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57766,
CC ChEBI:CHEBI:57980; EC=2.6.1.9;
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000250};
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent
CC aminotransferase family. Histidinol-phosphate aminotransferase
CC subfamily. {ECO:0000305}.
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DR EMBL; AE004439; AAK02922.1; -; Genomic_DNA.
DR RefSeq; WP_010906872.1; NC_002663.1.
DR AlphaFoldDB; Q9CMI7; -.
DR SMR; Q9CMI7; -.
DR STRING; 747.DR93_1678; -.
DR EnsemblBacteria; AAK02922; AAK02922; PM0838.
DR KEGG; pmu:PM0838; -.
DR PATRIC; fig|272843.6.peg.849; -.
DR HOGENOM; CLU_017584_3_3_6; -.
DR OMA; NYHVAGF; -.
DR UniPathway; UPA00031; UER00012.
DR Proteomes; UP000000809; Chromosome.
DR GO; GO:0004400; F:histidinol-phosphate transaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR HAMAP; MF_01023; HisC_aminotrans_2; 1.
DR InterPro; IPR001917; Aminotrans_II_pyridoxalP_BS.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR005861; HisP_aminotrans.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; SSF53383; 1.
DR TIGRFAMs; TIGR01141; hisC; 1.
DR PROSITE; PS00599; AA_TRANSFER_CLASS_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aminotransferase; Histidine biosynthesis;
KW Pyridoxal phosphate; Reference proteome; Transferase.
FT CHAIN 1..365
FT /note="Histidinol-phosphate aminotransferase 2"
FT /id="PRO_0000153411"
FT MOD_RES 226
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 365 AA; 40250 MW; F2049EDE8ABCAA85 CRC64;
MQYINIVNEG VKQLHPYQAG KPIEELEREL GITNIIKLAS NENPFGLPDS AKQAILAELD
NLTRYPDSNG FYFKQTVAKK FGLSPEQITL GNGSNDLLEL VAHTFANEQD EILFSQYAFI
VYPLVTQAIN AKKVEIPAKN YGADLDGFLQ AISDKTKLIY LANPNNPTGT FLSAGEISQF
LNQVPAHVIV VLDEAYTEFT LPEERVDSFT LLKKHSNLVI CRTLSKAYGL AGLRIGYAVS
SAEIADLFNR VRQPFNCNSL ALAAATAVLH DDAFIAKVAE NNRQGLKLLE DFFTAKGLNY
IPSKGNFVML DVNQPALPIY QALLQKGVIV RPIAGYGLPN HLRISIGLPE ENQRFLLALN
EVLGL