ANR_PSEAE
ID ANR_PSEAE Reviewed; 244 AA.
AC P23926;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Transcriptional activator protein anr;
GN Name=anr; OrderedLocusNames=PA1544;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=1787797; DOI=10.1111/j.1365-2958.1991.tb00793.x;
RA Sawers R.G.;
RT "Identification and molecular characterization of a transcriptional
RT regulator from Pseudomonas aeruginosa PAO1 exhibiting structural and
RT functional similarity to the FNR protein of Escherichia coli.";
RL Mol. Microbiol. 5:1469-1481(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=1787798; DOI=10.1111/j.1365-2958.1991.tb00794.x;
RA Zimmermann A., Reimmann C., Galimand M., Haas D.;
RT "Anaerobic growth and cyanide synthesis of Pseudomonas aeruginosa depend on
RT anr, a regulatory gene homologous with fnr of Escherichia coli.";
RL Mol. Microbiol. 5:1483-1490(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RA Savioz A., Zimmermann A., Haas D.;
RT "RpoN-independent promoters having a conserved GG-N10-GC motif in
RT Pseudomonas aeruginosa.";
RL Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Transcriptional activator of anaerobic gene expression.
CC -!- MISCELLANEOUS: Possesses 4 cysteines which may bind a metal ion
CC (possibly iron).
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DR EMBL; X58405; CAA41305.1; -; Genomic_DNA.
DR EMBL; X57736; CAA40906.1; -; Genomic_DNA.
DR EMBL; M98276; AAA25713.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG04933.1; -; Genomic_DNA.
DR PIR; S16307; S16307.
DR RefSeq; NP_250235.1; NC_002516.2.
DR RefSeq; WP_003087262.1; NZ_QZGE01000032.1.
DR AlphaFoldDB; P23926; -.
DR SMR; P23926; -.
DR STRING; 287.DR97_392; -.
DR PaxDb; P23926; -.
DR PRIDE; P23926; -.
DR EnsemblBacteria; AAG04933; AAG04933; PA1544.
DR GeneID; 883009; -.
DR KEGG; pae:PA1544; -.
DR PATRIC; fig|208964.12.peg.1597; -.
DR PseudoCAP; PA1544; -.
DR HOGENOM; CLU_075053_0_2_6; -.
DR InParanoid; P23926; -.
DR OMA; SICRIHK; -.
DR PhylomeDB; P23926; -.
DR BioCyc; PAER208964:G1FZ6-1572-MON; -.
DR PHI-base; PHI:4002; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0036294; P:cellular response to decreased oxygen levels; IMP:PseudoCAP.
DR GO; GO:0046202; P:cyanide biosynthetic process; IMP:PseudoCAP.
DR GO; GO:1900275; P:negative regulation of phospholipase C activity; IMP:PseudoCAP.
DR GO; GO:0051353; P:positive regulation of oxidoreductase activity; IMP:PseudoCAP.
DR GO; GO:1900081; P:regulation of arginine catabolic process; IMP:PseudoCAP.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:PseudoCAP.
DR GO; GO:0036293; P:response to decreased oxygen levels; IDA:PseudoCAP.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR012318; HTH_CRP.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR018335; Tscrpt_reg_HTH_Crp-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00325; Crp; 1.
DR PRINTS; PR00034; HTHCRP.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00419; HTH_CRP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS00042; HTH_CRP_1; 1.
DR PROSITE; PS51063; HTH_CRP_2; 1.
PE 4: Predicted;
KW Activator; DNA-binding; Iron; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..244
FT /note="Transcriptional activator protein anr"
FT /id="PRO_0000100142"
FT DOMAIN 159..232
FT /note="HTH crp-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT DNA_BIND 192..211
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT BINDING 21..149
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
SQ SEQUENCE 244 AA; 27129 MW; A57E6C0CFB32600B CRC64;
MAETIKVRAL PQAHCKDCSL APLCLPLSLT VEDMDSLDEI VKRGRPLKKG EFLFRQGDPF
GSVFAVRSGA LKTFSITDAG EEQITGFHLP SELVGLSGMD TETYPVSAQA LETTSVCEIP
FERLDELSEQ LPQLRRQLMR LMSREIRDDQ QMMLLLSKKT ADERIATFLV NLSARFRARG
FSAQQFRLAM SRNEIGNYLG LAVETVSRVF TRFQQNGLIS AEGKEVHILD SIELCALAGG
QLEG
