ID   ANS10_ANISI             Reviewed;         231 AA.
AC   D2K835;
DT   16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Allergen Ani s 10 {ECO:0000303|PubMed:21310242};
DE   AltName: Allergen=Ani s 10 {ECO:0000303|PubMed:21310242};
DE   Flags: Precursor;
OS   Anisakis simplex (Herring worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC   Anisakis simplex complex.
OX   NCBI_TaxID=6269 {ECO:0000312|EMBL:ACZ95445.1};
RN   [1] {ECO:0000312|EMBL:ACZ95445.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], BIOPHYSICOCHEMICAL PROPERTIES, AND ALLERGEN.
RC   TISSUE=Larva {ECO:0000303|PubMed:21310242};
RX   PubMed=21310242; DOI=10.1016/j.parint.2011.01.003;
RA   Caballero M.L., Umpierrez A., Moneo I., Rodriguez-Perez R.;
RT   "Ani s 10, a new Anisakis simplex allergen: Cloning and heterologous
RT   expression.";
RL   Parasitol. Int. 60:209-212(2011).
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Temperature dependence:
CC         Resistant to heat. {ECO:0000269|PubMed:21310242};
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE. A.simplex
CC       is a fish parasite that, when accidentally ingested by humans, may
CC       cause allergic reactions in sensitized individuals.
CC       {ECO:0000269|PubMed:21310242}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GU187358; ACZ95445.1; -; mRNA.
DR   AlphaFoldDB; D2K835; -.
DR   Allergome; 8428; Ani s 10.
DR   Allergome; 8429; Ani s 10.0101.
DR   Proteomes; UP000036680; Genome.
PE   1: Evidence at protein level;
KW   Allergen; Repeat; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..231
FT                   /note="Allergen Ani s 10"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5003032612"
FT   REPEAT          28..56
FT                   /note="1"
FT                   /evidence="ECO:0000305|PubMed:21310242"
FT   REPEAT          57..85
FT                   /note="2"
FT                   /evidence="ECO:0000305|PubMed:21310242"
FT   REPEAT          86..114
FT                   /note="3"
FT                   /evidence="ECO:0000305|PubMed:21310242"
FT   REPEAT          115..143
FT                   /note="4"
FT                   /evidence="ECO:0000305|PubMed:21310242"
FT   REPEAT          144..172
FT                   /note="5"
FT                   /evidence="ECO:0000305|PubMed:21310242"
FT   REPEAT          173..201
FT                   /note="6"
FT                   /evidence="ECO:0000305|PubMed:21310242"
FT   REPEAT          204..231
FT                   /note="7"
FT                   /evidence="ECO:0000305|PubMed:21310242"
FT   REGION          28..201
FT                   /note="6 X 29 AA tandem repeats of [EG]-G-P-G-P-V-[IV]-
FT                   [SG]-G-S-G-I-G-[ND]-V-W-[NE]-K-A-N-E-[QP]-A-[AE]-[QEH]-Q-
FT                   [EQ]-[NS]-I"
FT                   /evidence="ECO:0000305|PubMed:21310242"
FT   REGION          107..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   231 AA;  23284 MW;  63B7DCDF529056C9 CRC64;
     MHLITALVLL LQLIHFITSS PIPQEVVGGP GPVVGGSGIG NVWEKANEQA AEQQNIGGPG
     PVISGSGIGD VWNKANEPAE QQENIGGPGP VVSGSGIGNV WEKANEQAAH QQSIEGPGPV
     VSGSGIGNVW EKANEQAAHQ QSIEGPGPVV SGSGIGDVWN KANEQAAEQQ NIGGPGPVIS
     GSGIGNVWEK ANEQAAEQQN IGVGGPGPVK SGSGIGNVWE ETNEEAASMQ A