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ANS1B_DANRE
ID   ANS1B_DANRE             Reviewed;        1280 AA.
AC   A5PMU4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Ankyrin repeat and sterile alpha motif domain-containing protein 1B;
GN   Name=anks1b; ORFNames=si:ch211-211o1.2, si:dkey-11k24.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CT025647; CAN87827.1; -; Genomic_DNA.
DR   EMBL; BX890574; CAN87827.1; JOINED; Genomic_DNA.
DR   EMBL; BX897712; CAN87827.1; JOINED; Genomic_DNA.
DR   EMBL; BX901882; CAN87827.1; JOINED; Genomic_DNA.
DR   EMBL; BX897712; CAN88193.1; -; Genomic_DNA.
DR   EMBL; BX890574; CAN88193.1; JOINED; Genomic_DNA.
DR   EMBL; BX901882; CAN88193.1; JOINED; Genomic_DNA.
DR   EMBL; CT025647; CAN88193.1; JOINED; Genomic_DNA.
DR   EMBL; BX901882; CAN88370.1; -; Genomic_DNA.
DR   EMBL; BX890574; CAN88370.1; JOINED; Genomic_DNA.
DR   EMBL; BX897712; CAN88370.1; JOINED; Genomic_DNA.
DR   EMBL; CT025647; CAN88370.1; JOINED; Genomic_DNA.
DR   EMBL; BX890574; CAN88710.1; -; Genomic_DNA.
DR   EMBL; BX897712; CAN88710.1; JOINED; Genomic_DNA.
DR   EMBL; BX901882; CAN88710.1; JOINED; Genomic_DNA.
DR   EMBL; CT025647; CAN88710.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001093487.1; NM_001100017.2.
DR   AlphaFoldDB; A5PMU4; -.
DR   SMR; A5PMU4; -.
DR   STRING; 7955.ENSDARP00000025800; -.
DR   PaxDb; A5PMU4; -.
DR   PeptideAtlas; A5PMU4; -.
DR   PRIDE; A5PMU4; -.
DR   Ensembl; ENSDART00000133509; ENSDARP00000117040; ENSDARG00000003512.
DR   GeneID; 565408; -.
DR   KEGG; dre:565408; -.
DR   CTD; 56899; -.
DR   ZFIN; ZDB-GENE-041210-349; anks1b.
DR   eggNOG; KOG0507; Eukaryota.
DR   GeneTree; ENSGT00940000154572; -.
DR   InParanoid; A5PMU4; -.
DR   PhylomeDB; A5PMU4; -.
DR   PRO; PR:A5PMU4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 4.
DR   Bgee; ENSDARG00000003512; Expressed in cardiac ventricle and 18 other tissues.
DR   ExpressionAtlas; A5PMU4; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0046875; F:ephrin receptor binding; IBA:GO_Central.
DR   GO; GO:0048013; P:ephrin receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:1900383; P:regulation of synaptic plasticity by receptor localization to synapse; IEA:InterPro.
DR   CDD; cd09499; SAM_AIDA1AB-like_repeat1; 1.
DR   CDD; cd09500; SAM_AIDA1AB-like_repeat2; 1.
DR   Gene3D; 1.10.150.50; -; 2.
DR   Gene3D; 1.25.40.20; -; 2.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR033636; ANKS1B.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041880; SAM_ANKS1_repeat1.
DR   InterPro; IPR041882; SAM_ANKS1_repeat2.
DR   PANTHER; PTHR24174:SF3; PTHR24174:SF3; 1.
DR   Pfam; PF12796; Ank_2; 3.
DR   Pfam; PF00640; PID; 1.
DR   Pfam; PF00536; SAM_1; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00454; SAM; 2.
DR   SUPFAM; SSF47769; SSF47769; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS01179; PID; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Cytoplasm; Reference proteome; Repeat.
FT   CHAIN           1..1280
FT                   /note="Ankyrin repeat and sterile alpha motif domain-
FT                   containing protein 1B"
FT                   /id="PRO_0000327262"
FT   REPEAT          2..31
FT                   /note="ANK 1"
FT   REPEAT          57..86
FT                   /note="ANK 2"
FT   REPEAT          90..119
FT                   /note="ANK 3"
FT   REPEAT          126..155
FT                   /note="ANK 4"
FT   REPEAT          159..188
FT                   /note="ANK 5"
FT   REPEAT          192..221
FT                   /note="ANK 6"
FT   REPEAT          224..253
FT                   /note="ANK 7"
FT   DOMAIN          824..890
FT                   /note="SAM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   DOMAIN          898..963
FT                   /note="SAM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   DOMAIN          1071..1223
FT                   /note="PID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT   REGION          299..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          704..723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          755..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          960..994
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1208..1243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        767..787
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        979..994
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1280 AA;  141494 MW;  CB5BAE048770AEB0 CRC64;
     MGKEQELLEA ARTGNVGLVE KLLSGKKGLL GSGSGSIPLP GLLSMWRGLN VNCVDGSGYT
     PLHHASLNGH RDVVLKLLQF EASTNVSDSK GCFPLHLAAW RGDVDIVQIL IHHGPSHSRV
     NEQNLEKETA LHCAAQYGHS EVVRVLLQEL TDPSMRNSRG ETPLDLAALY GRLQVVRMLL
     TAHPNLMSCN TRKHTPLHLA ARNGHYATVQ VLLEADMDVN TQTEKGSALH EAALFGKMDV
     VQLLLDSGID ANIRDCQGRT ALDILREHPS QKSQQIASLI HDYMMSDCDR GNFHEDLARH
     RPIPTPRTSI PSPVPSPSLR HKNDAVTGEL SKLLNEIKIC RDKDCSFEEL CQTISSHSQS
     MESFGSGRLS DEERNGTLTR INKRPTPPLP PALEEEEKSC GPSGLWEALT PCNGCRNLGF
     SQDKRCVEIA HSPSLDVFLP EDEDNPYESV ATAVTRKPCS LDINLHNACP RNGHFSHVSV
     SDAERGNHGD DSTGLTPDCS PPSPDTALRN IERVIRPQPK QRTSLSSSQD VQKPLQNHSG
     DPSEVSSSLG YASFSTSPPA SPPISPANCS TGSAEDYALT DEATYQKECI ERDDRRNSHV
     PEQFAGLLHG SSPACESPDN PYQLYGKVRK FSVPEPPLRH GNFLRAPEYS PPFPRTGSEA
     SALKTQREVK PQVVYRTIFH TRVNQGPVTF GEQVDKTTGV HARNGEARSN CTGGSSPANS
     NTGYEERACT LGRMRSMPKN VLDLQLSRNF SKSDSNLVAV SPIEEEQWGS RGQSSPGKSS
     PSRLERTPSF TAEWEEIDKI MSSIGAGIGT EMEGITEDHP GPRCPVQSVG QWLDNIGLVQ
     YENHLLSNGF DNVQFMGSNV VEDQDLLEIG ILNSAHRQRL LQAIRLLPRV RPIGYDGNNP
     TSVAEWLESL ELGDYTKSFL INGYTSMELV KKIWEIELIN VLKINLIGHR KRILASLGDR
     LHEDPPQKPP RAISLREPTG NHTPPQLSPS LSQAYPNAGS LDVQHLIMQA DARRRRNDNY
     FEDVPRSKLE RQMAQVSMQG EWCEPITLRP PNEATSSTPV QYWQHHPEKL IFQSCDYEAY
     YLGSMLVKEL RGTESTHDAC AKMRSTEQMK KIPTIVLSVS YKGVKFIDAT NKNIIAEHEI
     RNISCAAQDP EDLSTFAYIT KDLKSSHHYC HVFTAFDVNL AYEIILTLGQ AFEVAYQLAL
     QARKSGHGSS TLPESFDSKP SKPVPKPRGN IRKSMEQPSM DQKGHANVPW IVEPGQEAKR
     GANTKAMADA HVYYSGIQRM
 
 
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