ANS1B_DANRE
ID ANS1B_DANRE Reviewed; 1280 AA.
AC A5PMU4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Ankyrin repeat and sterile alpha motif domain-containing protein 1B;
GN Name=anks1b; ORFNames=si:ch211-211o1.2, si:dkey-11k24.3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; CT025647; CAN87827.1; -; Genomic_DNA.
DR EMBL; BX890574; CAN87827.1; JOINED; Genomic_DNA.
DR EMBL; BX897712; CAN87827.1; JOINED; Genomic_DNA.
DR EMBL; BX901882; CAN87827.1; JOINED; Genomic_DNA.
DR EMBL; BX897712; CAN88193.1; -; Genomic_DNA.
DR EMBL; BX890574; CAN88193.1; JOINED; Genomic_DNA.
DR EMBL; BX901882; CAN88193.1; JOINED; Genomic_DNA.
DR EMBL; CT025647; CAN88193.1; JOINED; Genomic_DNA.
DR EMBL; BX901882; CAN88370.1; -; Genomic_DNA.
DR EMBL; BX890574; CAN88370.1; JOINED; Genomic_DNA.
DR EMBL; BX897712; CAN88370.1; JOINED; Genomic_DNA.
DR EMBL; CT025647; CAN88370.1; JOINED; Genomic_DNA.
DR EMBL; BX890574; CAN88710.1; -; Genomic_DNA.
DR EMBL; BX897712; CAN88710.1; JOINED; Genomic_DNA.
DR EMBL; BX901882; CAN88710.1; JOINED; Genomic_DNA.
DR EMBL; CT025647; CAN88710.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001093487.1; NM_001100017.2.
DR AlphaFoldDB; A5PMU4; -.
DR SMR; A5PMU4; -.
DR STRING; 7955.ENSDARP00000025800; -.
DR PaxDb; A5PMU4; -.
DR PeptideAtlas; A5PMU4; -.
DR PRIDE; A5PMU4; -.
DR Ensembl; ENSDART00000133509; ENSDARP00000117040; ENSDARG00000003512.
DR GeneID; 565408; -.
DR KEGG; dre:565408; -.
DR CTD; 56899; -.
DR ZFIN; ZDB-GENE-041210-349; anks1b.
DR eggNOG; KOG0507; Eukaryota.
DR GeneTree; ENSGT00940000154572; -.
DR InParanoid; A5PMU4; -.
DR PhylomeDB; A5PMU4; -.
DR PRO; PR:A5PMU4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000003512; Expressed in cardiac ventricle and 18 other tissues.
DR ExpressionAtlas; A5PMU4; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0046875; F:ephrin receptor binding; IBA:GO_Central.
DR GO; GO:0048013; P:ephrin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1900383; P:regulation of synaptic plasticity by receptor localization to synapse; IEA:InterPro.
DR CDD; cd09499; SAM_AIDA1AB-like_repeat1; 1.
DR CDD; cd09500; SAM_AIDA1AB-like_repeat2; 1.
DR Gene3D; 1.10.150.50; -; 2.
DR Gene3D; 1.25.40.20; -; 2.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR033636; ANKS1B.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041880; SAM_ANKS1_repeat1.
DR InterPro; IPR041882; SAM_ANKS1_repeat2.
DR PANTHER; PTHR24174:SF3; PTHR24174:SF3; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00454; SAM; 2.
DR SUPFAM; SSF47769; SSF47769; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 3: Inferred from homology;
KW ANK repeat; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..1280
FT /note="Ankyrin repeat and sterile alpha motif domain-
FT containing protein 1B"
FT /id="PRO_0000327262"
FT REPEAT 2..31
FT /note="ANK 1"
FT REPEAT 57..86
FT /note="ANK 2"
FT REPEAT 90..119
FT /note="ANK 3"
FT REPEAT 126..155
FT /note="ANK 4"
FT REPEAT 159..188
FT /note="ANK 5"
FT REPEAT 192..221
FT /note="ANK 6"
FT REPEAT 224..253
FT /note="ANK 7"
FT DOMAIN 824..890
FT /note="SAM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 898..963
FT /note="SAM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 1071..1223
FT /note="PID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT REGION 299..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1280 AA; 141494 MW; CB5BAE048770AEB0 CRC64;
MGKEQELLEA ARTGNVGLVE KLLSGKKGLL GSGSGSIPLP GLLSMWRGLN VNCVDGSGYT
PLHHASLNGH RDVVLKLLQF EASTNVSDSK GCFPLHLAAW RGDVDIVQIL IHHGPSHSRV
NEQNLEKETA LHCAAQYGHS EVVRVLLQEL TDPSMRNSRG ETPLDLAALY GRLQVVRMLL
TAHPNLMSCN TRKHTPLHLA ARNGHYATVQ VLLEADMDVN TQTEKGSALH EAALFGKMDV
VQLLLDSGID ANIRDCQGRT ALDILREHPS QKSQQIASLI HDYMMSDCDR GNFHEDLARH
RPIPTPRTSI PSPVPSPSLR HKNDAVTGEL SKLLNEIKIC RDKDCSFEEL CQTISSHSQS
MESFGSGRLS DEERNGTLTR INKRPTPPLP PALEEEEKSC GPSGLWEALT PCNGCRNLGF
SQDKRCVEIA HSPSLDVFLP EDEDNPYESV ATAVTRKPCS LDINLHNACP RNGHFSHVSV
SDAERGNHGD DSTGLTPDCS PPSPDTALRN IERVIRPQPK QRTSLSSSQD VQKPLQNHSG
DPSEVSSSLG YASFSTSPPA SPPISPANCS TGSAEDYALT DEATYQKECI ERDDRRNSHV
PEQFAGLLHG SSPACESPDN PYQLYGKVRK FSVPEPPLRH GNFLRAPEYS PPFPRTGSEA
SALKTQREVK PQVVYRTIFH TRVNQGPVTF GEQVDKTTGV HARNGEARSN CTGGSSPANS
NTGYEERACT LGRMRSMPKN VLDLQLSRNF SKSDSNLVAV SPIEEEQWGS RGQSSPGKSS
PSRLERTPSF TAEWEEIDKI MSSIGAGIGT EMEGITEDHP GPRCPVQSVG QWLDNIGLVQ
YENHLLSNGF DNVQFMGSNV VEDQDLLEIG ILNSAHRQRL LQAIRLLPRV RPIGYDGNNP
TSVAEWLESL ELGDYTKSFL INGYTSMELV KKIWEIELIN VLKINLIGHR KRILASLGDR
LHEDPPQKPP RAISLREPTG NHTPPQLSPS LSQAYPNAGS LDVQHLIMQA DARRRRNDNY
FEDVPRSKLE RQMAQVSMQG EWCEPITLRP PNEATSSTPV QYWQHHPEKL IFQSCDYEAY
YLGSMLVKEL RGTESTHDAC AKMRSTEQMK KIPTIVLSVS YKGVKFIDAT NKNIIAEHEI
RNISCAAQDP EDLSTFAYIT KDLKSSHHYC HVFTAFDVNL AYEIILTLGQ AFEVAYQLAL
QARKSGHGSS TLPESFDSKP SKPVPKPRGN IRKSMEQPSM DQKGHANVPW IVEPGQEAKR
GANTKAMADA HVYYSGIQRM