ANS1_YEAST
ID ANS1_YEAST Reviewed; 159 AA.
AC P38832; D3DL75;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Probable GPI-anchored protein ANS1;
DE Flags: Precursor;
GN Name=ANS1; OrderedLocusNames=YHR126C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP INDUCTION.
RX PubMed=16467472; DOI=10.1128/ec.5.2.313-320.2006;
RA Slattery M.G., Liko D., Heideman W.;
RT "The function and properties of the Azf1 transcriptional regulator change
RT with growth conditions in Saccharomyces cerevisiae.";
RL Eukaryot. Cell 5:313-320(2006).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- INDUCTION: Expression is regulated by AZF1.
CC {ECO:0000269|PubMed:16467472}.
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DR EMBL; U10398; AAB68411.1; -; Genomic_DNA.
DR EMBL; AY692674; AAT92693.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06819.1; -; Genomic_DNA.
DR PIR; S48970; S48970.
DR RefSeq; NP_011994.1; NM_001179256.1.
DR AlphaFoldDB; P38832; -.
DR BioGRID; 36559; 15.
DR STRING; 4932.YHR126C; -.
DR PaxDb; P38832; -.
DR EnsemblFungi; YHR126C_mRNA; YHR126C; YHR126C.
DR GeneID; 856527; -.
DR KEGG; sce:YHR126C; -.
DR SGD; S000001168; ANS1.
DR VEuPathDB; FungiDB:YHR126C; -.
DR HOGENOM; CLU_1678931_0_0_1; -.
DR BioCyc; YEAST:G3O-31166-MON; -.
DR PRO; PR:P38832; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38832; protein.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005199; F:structural constituent of cell wall; IEA:InterPro.
DR InterPro; IPR000420; Yeast_PIR.
DR Pfam; PF00399; PIR; 1.
DR PROSITE; PS00929; PIR_REPEAT_1; 1.
DR PROSITE; PS50256; PIR_REPEAT_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..137
FT /note="Probable GPI-anchored protein ANS1"
FT /id="PRO_0000203777"
FT PROPEP 138..159
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000402190"
FT REPEAT 101..114
FT /note="PIR1/2/3"
FT LIPID 137
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 159 AA; 16635 MW; EFF6F5F5A6DEA211 CRC64;
MKCTLVSTLF AITNILVAHA QVSNSSDTLD VQFANSTNSY IEGKFNSTDE AFNSSASWSL
AAQQKKISNA AVYDVGGWNG SLYRSNRSAV ADHQPGKKQD AAISQISDGQ IQATASGPET
TAATTPSSTA NVSVYEGAGM KVESKNMGYI VGVAALLFL
