HIS8_METMP
ID HIS8_METMP Reviewed; 371 AA.
AC P61003;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Histidinol-phosphate aminotransferase {ECO:0000255|HAMAP-Rule:MF_01023};
DE EC=2.6.1.9 {ECO:0000255|HAMAP-Rule:MF_01023};
DE AltName: Full=Imidazole acetol-phosphate transaminase {ECO:0000255|HAMAP-Rule:MF_01023};
GN Name=hisC {ECO:0000255|HAMAP-Rule:MF_01023}; OrderedLocusNames=MMP1216;
OS Methanococcus maripaludis (strain S2 / LL).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=267377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 / LL;
RX PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA Olson M.V., Leigh J.A.;
RT "Complete genome sequence of the genetically tractable hydrogenotrophic
RT methanogen Methanococcus maripaludis.";
RL J. Bacteriol. 186:6956-6969(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-
CC oxopropyl phosphate + L-glutamate; Xref=Rhea:RHEA:23744,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57766,
CC ChEBI:CHEBI:57980; EC=2.6.1.9; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01023};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01023};
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.
CC {ECO:0000255|HAMAP-Rule:MF_01023}.
CC -!- SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent
CC aminotransferase family. Histidinol-phosphate aminotransferase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01023}.
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DR EMBL; BX950229; CAF30772.1; -; Genomic_DNA.
DR RefSeq; WP_011171160.1; NC_005791.1.
DR AlphaFoldDB; P61003; -.
DR SMR; P61003; -.
DR STRING; 267377.MMP1216; -.
DR EnsemblBacteria; CAF30772; CAF30772; MMP1216.
DR GeneID; 2761452; -.
DR KEGG; mmp:MMP1216; -.
DR PATRIC; fig|267377.15.peg.1249; -.
DR eggNOG; arCOG04273; Archaea.
DR HOGENOM; CLU_017584_3_3_2; -.
DR OMA; IWLNANE; -.
DR OrthoDB; 69863at2157; -.
DR BioCyc; MMAR267377:MMP_RS06260-MON; -.
DR UniPathway; UPA00031; UER00012.
DR Proteomes; UP000000590; Chromosome.
DR GO; GO:0004400; F:histidinol-phosphate transaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR HAMAP; MF_01023; HisC_aminotrans_2; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR005861; HisP_aminotrans.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; SSF53383; 1.
DR TIGRFAMs; TIGR01141; hisC; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aminotransferase; Histidine biosynthesis;
KW Pyridoxal phosphate; Reference proteome; Transferase.
FT CHAIN 1..371
FT /note="Histidinol-phosphate aminotransferase"
FT /id="PRO_0000153500"
FT MOD_RES 228
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01023"
SQ SEQUENCE 371 AA; 42246 MW; 60D0EEDEF1F3C9F3 CRC64;
MSIDDKVRSI VKEFKAYVPG KSKEEIARNY GIDPERIIKL GSNENPWGCS PKIEEKLLNE
VSNLHQYPQP INPELMDEIS KFTKMPVENI IVGGDGADEV IDNIMRILID EGDEVIIPIP
TFTQYAISAK IHGANIKWAK FDEENGFKLD VESVLNNITE KTKAIFLCTP NNPTGNVIPT
EDIKKIVEST DALVMIDHAY IEYSKEEYDL TSWALKYDNV LVLRTFSKVF GLAGQRVGYG
VTSKKVVDYM MRIKPIFSLT RASQVSAITA LQDKEFFEKC LKEGIESREE IYNGLKKFKQ
LEVYPTEANY MLVKVKNGMN SSEFCEALLK KGVIVRDCYS FEGLEPYYFR VSIGTSEENE
RFLKIMSEIV E