ID   ANSP1_MYCTU             Reviewed;         489 AA.
AC   P9WQM9; L0TBF4; O33261;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=L-asparagine permease 1;
DE   AltName: Full=L-asparagine transport protein 1;
GN   Name=ansP1; Synonyms=ansP; OrderedLocusNames=Rv2127; ORFNames=MTCY261.26;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44902.1; -; Genomic_DNA.
DR   PIR; B70514; B70514.
DR   RefSeq; WP_003899182.1; NZ_NVQJ01000044.1.
DR   RefSeq; YP_177863.1; NC_000962.3.
DR   AlphaFoldDB; P9WQM9; -.
DR   SMR; P9WQM9; -.
DR   STRING; 83332.Rv2127; -.
DR   PaxDb; P9WQM9; -.
DR   DNASU; 887715; -.
DR   GeneID; 887715; -.
DR   KEGG; mtu:Rv2127; -.
DR   TubercuList; Rv2127; -.
DR   eggNOG; COG1113; Bacteria.
DR   OMA; QVPYAGI; -.
DR   PhylomeDB; P9WQM9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   Pfam; PF00324; AA_permease; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..489
FT                   /note="L-asparagine permease 1"
FT                   /id="PRO_0000054189"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   489 AA;  52447 MW;  513556EFBE332DFC CRC64;
     MSAASQRVGA FGEEAGYHKG LKPRQLQMIG IGGAIGTGLF LGAGGRLAKA GPGLFLVYGV
     CGVFVFLILR ALGELVLHRP SSGSFVSYAR EFFGEKAAYA VGWMYFLHWA MTSIVDTTAI
     ATYLQRWTIF TVVPQWILAL IALTVVLSMN LISVEWFGEL EFWAALIKVL ALMAFLVVGT
     VFLAGRYPVD GHSTGLSLWN NHGGLFPTSW LPLLIVTSGV VFAYSAVELV GTAAGETAEP
     EKIMPRAINS VVARIAIFYV GSVALLALLL PYTAYKAGES PFVTFFSKIG FHGAGDLMNI
     VVLTAALSSL NAGLYSTGRV MHSIAMSGSA PRFTARMSKS GVPYGGIVLT AVITLFGVAL
     NAFKPGEAFE IVLNMSALGI IAGWATIVLC QLRLHKLANA GIMQRPRFRM PFSPYSGYLT
     LLFLLVVLVT MASDKPIGTW TVATLIIVIP ALTAGWYLVR KRVMAVARER LGHTGPFPAV
     ANPPVRSRD