ANT1_ASHGO
ID ANT1_ASHGO Reviewed; 340 AA.
AC Q75A82;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Peroxisomal adenine nucleotide transporter 1;
GN Name=ANT1; OrderedLocusNames=ADR036C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Adenine nucleotide transporter involved in the uniport of ATP
CC and adenine nucleotide hetero-exchange transport between the cytosol
CC and the peroxisomal lumen. This transport is accompanied by a proton
CC transport from the peroxisomal lumen to the cytosol. Transport of ATP
CC into the peroxisome is required for beta-oxidation of medium-chain
CC fatty acids (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AE016817; AAS51956.1; -; Genomic_DNA.
DR RefSeq; NP_984132.1; NM_209485.1.
DR AlphaFoldDB; Q75A82; -.
DR SMR; Q75A82; -.
DR STRING; 33169.AAS51956; -.
DR EnsemblFungi; AAS51956; AAS51956; AGOS_ADR036C.
DR GeneID; 4620281; -.
DR KEGG; ago:AGOS_ADR036C; -.
DR eggNOG; KOG0769; Eukaryota.
DR HOGENOM; CLU_015166_6_3_1; -.
DR InParanoid; Q75A82; -.
DR OMA; PLEMINT; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0015217; F:ADP transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015866; P:ADP transport; IBA:GO_Central.
DR GO; GO:0015867; P:ATP transport; IBA:GO_Central.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR GO; GO:0007031; P:peroxisome organization; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR045900; Peroxisomal_Ade_carrier.
DR PANTHER; PTHR46650; PTHR46650; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Hydrogen ion transport; Ion transport; Membrane; Peroxisome;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..340
FT /note="Peroxisomal adenine nucleotide transporter 1"
FT /id="PRO_0000227602"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 4..119
FT /note="Solcar 1"
FT REPEAT 133..218
FT /note="Solcar 2"
FT REPEAT 236..320
FT /note="Solcar 3"
SQ SEQUENCE 340 AA; 37170 MW; D54390638E55B31D CRC64;
MSFENAVIGA TASSLANIAV YPLDLAKTLV QTQLKDEFVE AGEEAGEERA GSRRQNRIKP
IALRSPQAAE QYKGALDALQ RIYGAEGVAG LYRGLGSSTV AGFIQSFSYF FWYTLVRKHY
FRLKQARGGD ARFSTPEELV LGIVAAATSQ LFVNPINVVA TRQQTRGQAA GAADMRTVAR
EVHAENGWRG FWAGLKVSLV LTVNPSITYA TYERLREALF PTPAAASHLV DSAALLSPGQ
NFVMGVLSKI VSTVLTQPLI IAKASLQRSG SCFQDFHQVL HHLYSTEGPL SLWKGLGPQI
TKGVLVQGLL FMFKGELTKM LRKLMFYLAL LRSSRRALKG
