ID   ANT1_ONCVO              Reviewed;        2022 AA.
AC   P21249; Q25614;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Major antigen;
DE   AltName: Full=Myosin-like antigen;
GN   Name=OVT1;
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7770081; DOI=10.1016/0166-6851(94)00187-r;
RA   Triteeraprapab S., Richie T.L., Tuan R.S., Shepley K.J., Dinman J.D.,
RA   Neubert T.A., Scott A.L.;
RT   "Molecular cloning of a gene expressed during early embryonic development
RT   in Onchocerca volvulus.";
RL   Mol. Biochem. Parasitol. 69:161-171(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 733-866.
RX   PubMed=2464764; DOI=10.1016/0166-6851(88)90154-5;
RA   Donelson J.E., Duke B.O.L., Moser D., Zeng W., Erondu N.E., Lucius R.,
RA   Renz A., Karam M., Flores G.Z.;
RT   "Construction of Onchocerca volvulus cDNA libraries and partial
RT   characterization of the cDNA for a major antigen.";
RL   Mol. Biochem. Parasitol. 31:241-250(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1020-1363.
RX   PubMed=2194123; DOI=10.1016/0166-6851(90)90043-l;
RA   Ngozi E., Erondu N.E., Donelson J.E.;
RT   "Characterization of a myosin-like antigen from Onchocerca volvulus.";
RL   Mol. Biochem. Parasitol. 40:213-224(1990).
CC   -!- FUNCTION: May be a myofibrillar protein.
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DR   EMBL; U12681; AAA80009.1; -; mRNA.
DR   EMBL; J03995; AAA29412.1; -; mRNA.
DR   EMBL; M30400; AAA29414.1; -; Genomic_DNA.
DR   EMBL; M30399; AAA29414.1; JOINED; Genomic_DNA.
DR   PIR; T43214; T43214.
DR   AlphaFoldDB; P21249; -.
DR   SMR; P21249; -.
DR   STRING; 6282.P21249; -.
DR   PRIDE; P21249; -.
DR   HOGENOM; CLU_000978_0_0_1; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..2022
FT                   /note="Major antigen"
FT                   /id="PRO_0000064603"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1944..2022
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          74..120
FT                   /evidence="ECO:0000255"
FT   COILED          151..251
FT                   /evidence="ECO:0000255"
FT   COILED          327..384
FT                   /evidence="ECO:0000255"
FT   COILED          417..1879
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..32
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1946..1972
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1973..1987
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        1038
FT                   /note="Missing (in Ref. 3; AAA29414)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1048
FT                   /note="P -> S (in Ref. 3; AAA29414)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1284
FT                   /note="A -> E (in Ref. 3; AAA29414)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2022 AA;  237342 MW;  B7132AACF1520317 CRC64;
     MEKAREGAPS KERRSAEETI SRETRHEIAG NDGDIGTDNI EYIDSMDSTG LGYGRTGEGI
     SRILYEHPRD ELINYKRRID ANTEQQREHA DIMAALQRKI EEYRRRFAEI EGRLVVHDLN
     ESGDLVNMKL KEEWLLSPKI KMEEISDVDF PNQLEDERRR AEDLAIQLQQ ERLQNDQLQS
     EIQRLRQQFG ICIRDKERIY QTRERNFTRF LGEEQRKMME LWSELQRVRK QCAEYREQTE
     RDLENQRNEF IKVIRHVSGI VRGLNIENGT HTLLSDLSSE SGVEITQDTV LIEAVKRFHE
     SQQQTAPVIG PELITELRLA RAEDAGLHDE LMRKYEESAK RIIELEARDD ESHNKLVALE
     SDLKRTRDRL AESQNALRKL YDMTYSYEIN AEKETRSPSP TKGYVPPPEV VRSVRYVLNS
     RANDNNVLQR KLKNAEVQIS ELTTKNDSLE EIRRRLEKRI AEANRTITHR QRELDDAKHT
     VKDLEDRLKS LEQEKASIDS ARHHLEDEIR KMREQFNSTL LDVERRAAED ADERIRKIDE
     ETKIRISELT NRIEMLLEEN KRLKDENDGM KNRIQDIEKE YNTIIRKLEE KDNALKNLEN
     TRQRLVNELE EQRTRFDTMT SEFDNLRTNY DSANKNTVAI ELTVKQIKEQ RDEIIKQKDK
     LAKELADLEN KLNNETKMRG DAEKLNQRHL DEIDNFKKQI NEYITEVTII RRQNDDFDTQ
     MKTNQAKLSS MKNSLIAAKK EIEKLSEMNN RLQQDKNDLI GAKQKGDTEL NLLTEKIRKV
     EIEFERIKKD NQELEDHERT ARDDLKQETN RNHLLAKELE EARADIVALN DRLAKMDANF
     KIKLDETIKK SPADHETIKS RESKSEKIIV KHETKIYEIN KYRAELEKLE SDKDDLEKRI
     IGLQDELNEK DRDTDRLNAE IDDLKRKLQT EIEKVRKETT TVQERYHIEW DEERDNHQKK
     IDSMNALIDE LRSKLNDAER AMADLQNRDS ILERENNDWK EKSDALNMEL DRLRDELLSV
     RRDAEKEINR YNTDLQTAAR NEIKLLTPTN NEMKSQLNAA EDKINSLNKV ITDQQNKIRD
     LTGEVHHLEG ELKDAKGNVA NLESELDTTR ERIHLLGEQN ASLQTELNKI KGDIDSLFGE
     NDMLKTAKES NEAEIDRLKQ KLQRSIENAK KYSDALDKLR PEYDRLQNLY REKIKQAENL
     TQAVQDLESR LNQSRRELRD ATDKLIASEG DRNALRSEVE KLQHEVQFMR EQLLRKTDEY
     QAALSDLVNA HRTAEDGRVN AVQALEARKY EINDLQSRLD NAEQYLVTLQ QNYVAVENER
     DMLYDALRRL HSMIDRTVTI NRFLIGVDES MDEKKETVLQ TQKSPDGKSK ERFDISDLDT
     NIQKLIGRIE KLELERNEYR DALDRIKKKS IESHIKINKQ ETIFTNIEDQ LVDVEEEKRT
     LEMRLASAKQ LLRSQEEALK QRDEERSHMK LKIAKFEMEA RGKEAQLRQL NELVRNLRKD
     LETAQGDLGV LHDHEERWYA HKFHLESKLK DQESESQQIR LLVANFETER NSLNEKVRDL
     ASRLQQTESK NADMKEDNDR LKKDLIKAST NEAELRRTID QNSRVVSDNQ ILKDQLESAQ
     NDLSNANNRK QQLENELLVV RSELRDLKQR FSDNANRIID LQRHLTDAEN DKKRLTNRLN
     SLEKTVSQQR TIETEIRQQL SLALNERNTL QNDLRDLQRR LARMETEKKI MNDKYDELEK
     IRASLIKRIE LLDEEKRTME NILHETALQR EAIESSLNAL ERENKELHRN CAQLQQQIAQ
     LELENGNRLI QLTNKQREEY DKFAQNMRTE KIQIERIIEN RERSLKSRIN QLENQLNIMR
     DQLNSERRRR REISDKILSG EVNKLNVTLS GIPDAYEMYD RTLYTYNTYF GSPSFTVGSS
     SFDPNITDDS KIILKHSDRL ESSYAYGGGN RTSDTAVTAP TGSSSYHGQR SDTHTVNESE
     RGGNDSGKGT KQVDGEGGSL SLSEIGQGAT FEQQQQRRRK RQ