ID   ANT3_MESAU              Reviewed;          25 AA.
AC   P81050;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Antithrombin-III;
DE            Short=ATIII;
DE   AltName: Full=Serpin C1;
DE   Flags: Fragment;
GN   Name=SERPINC1; Synonyms=AT3;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=8896339; DOI=10.1016/0305-0491(96)00114-9;
RA   Mak P., Enghild J.J., Dubin A.;
RT   "Hamster antithrombin III: purification, characterization and acute phase
RT   response.";
RL   Comp. Biochem. Physiol. 115B:135-141(1996).
CC   -!- FUNCTION: Most important serine protease inhibitor in plasma that
CC       regulates the blood coagulation cascade. AT-III inhibits thrombin,
CC       matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its
CC       inhibitory activity is greatly enhanced in the presence of heparin (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms protease inhibiting heterodimer with TMPRSS7.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Plasma.
CC   -!- PTM: Phosphorylated by FAM20C in the extracellular medium.
CC       {ECO:0000250|UniProtKB:P01008}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   STRING; 10036.XP_005071522.1; -.
DR   MEROPS; I04.026; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Blood coagulation; Direct protein sequencing; Hemostasis; Heparin-binding;
KW   Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..>25
FT                   /note="Antithrombin-III"
FT                   /id="PRO_0000094124"
FT   NON_TER         25
SQ   SEQUENCE   25 AA;  2876 MW;  9F06BF68046927D4 CRC64;
     NPVDDIXIAK PRDIPMNPMX IYRSP