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HIS9_ALKHC
ID   HIS9_ALKHC              Reviewed;         273 AA.
AC   Q9K801;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Histidinol-phosphatase;
DE            Short=HolPase;
DE            EC=3.1.3.15;
GN   Name=hisK; OrderedLocusNames=BH3206;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate;
CC         Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
CC   -!- SIMILARITY: Belongs to the PHP hydrolase family. HisK subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BA000004; BAB06925.1; -; Genomic_DNA.
DR   PIR; F84050; F84050.
DR   RefSeq; WP_010899349.1; NC_002570.2.
DR   AlphaFoldDB; Q9K801; -.
DR   SMR; Q9K801; -.
DR   STRING; 272558.10175829; -.
DR   EnsemblBacteria; BAB06925; BAB06925; BAB06925.
DR   KEGG; bha:BH3206; -.
DR   eggNOG; COG1387; Bacteria.
DR   HOGENOM; CLU_054611_2_1_9; -.
DR   OMA; KRIGHIT; -.
DR   OrthoDB; 1615112at2; -.
DR   UniPathway; UPA00031; UER00013.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0004401; F:histidinol-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR010140; Histidinol_P_phosphatase_HisJ.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   PANTHER; PTHR21039; PTHR21039; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR01856; hisJ_fam; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Hydrolase;
KW   Reference proteome.
FT   CHAIN           1..273
FT                   /note="Histidinol-phosphatase"
FT                   /id="PRO_0000122315"
SQ   SEQUENCE   273 AA;  30727 MW;  33173A153BA152E6 CRC64;
     MGKHDGHVHT PFCPHGTKDS FDAYCERAIS LGFTSLSFTE HAPLPKGFTD PTPAQDSSIG
     WNELDDYIHT LSSIKKAYRD QLTIYIGLEV DFIEGFEEEI CTFLNEYGPL LDDSLLSVHF
     LKHSDRYFCI DYSPDVFAVA IRTFGSIQAV YDTYYRTLER SITSELGPYK PKRIGHMTLV
     NKFQKKFPAP STEHQKKSQL EILQLVKKHG YSLDYNGAGF IKPLCGESYP PESIAKEAVA
     LGIPLIYGSD AHQAKALATG WEQMTPTLKN QDE
 
 
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