HIS9_ALKHC
ID HIS9_ALKHC Reviewed; 273 AA.
AC Q9K801;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Histidinol-phosphatase;
DE Short=HolPase;
DE EC=3.1.3.15;
GN Name=hisK; OrderedLocusNames=BH3206;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate;
CC Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15;
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
CC -!- SIMILARITY: Belongs to the PHP hydrolase family. HisK subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000004; BAB06925.1; -; Genomic_DNA.
DR PIR; F84050; F84050.
DR RefSeq; WP_010899349.1; NC_002570.2.
DR AlphaFoldDB; Q9K801; -.
DR SMR; Q9K801; -.
DR STRING; 272558.10175829; -.
DR EnsemblBacteria; BAB06925; BAB06925; BAB06925.
DR KEGG; bha:BH3206; -.
DR eggNOG; COG1387; Bacteria.
DR HOGENOM; CLU_054611_2_1_9; -.
DR OMA; KRIGHIT; -.
DR OrthoDB; 1615112at2; -.
DR UniPathway; UPA00031; UER00013.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0004401; F:histidinol-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010140; Histidinol_P_phosphatase_HisJ.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR PANTHER; PTHR21039; PTHR21039; 1.
DR Pfam; PF02811; PHP; 1.
DR SUPFAM; SSF89550; SSF89550; 1.
DR TIGRFAMs; TIGR01856; hisJ_fam; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Histidine biosynthesis; Hydrolase;
KW Reference proteome.
FT CHAIN 1..273
FT /note="Histidinol-phosphatase"
FT /id="PRO_0000122315"
SQ SEQUENCE 273 AA; 30727 MW; 33173A153BA152E6 CRC64;
MGKHDGHVHT PFCPHGTKDS FDAYCERAIS LGFTSLSFTE HAPLPKGFTD PTPAQDSSIG
WNELDDYIHT LSSIKKAYRD QLTIYIGLEV DFIEGFEEEI CTFLNEYGPL LDDSLLSVHF
LKHSDRYFCI DYSPDVFAVA IRTFGSIQAV YDTYYRTLER SITSELGPYK PKRIGHMTLV
NKFQKKFPAP STEHQKKSQL EILQLVKKHG YSLDYNGAGF IKPLCGESYP PESIAKEAVA
LGIPLIYGSD AHQAKALATG WEQMTPTLKN QDE