ID   HIS9_CLOAB              Reviewed;         255 AA.
AC   P58291;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Probable histidinol-phosphatase;
DE            Short=HolPase;
DE            EC=3.1.3.15;
GN   Name=hisK; OrderedLocusNames=CA_C2727;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate;
CC         Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
CC   -!- SIMILARITY: Belongs to the PHP hydrolase family. HisK subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE001437; AAK80673.1; -; Genomic_DNA.
DR   PIR; F97235; F97235.
DR   RefSeq; NP_349333.1; NC_003030.1.
DR   RefSeq; WP_010966014.1; NC_003030.1.
DR   AlphaFoldDB; P58291; -.
DR   SMR; P58291; -.
DR   STRING; 272562.CA_C2727; -.
DR   DNASU; 1118910; -.
DR   EnsemblBacteria; AAK80673; AAK80673; CA_C2727.
DR   GeneID; 44999215; -.
DR   KEGG; cac:CA_C2727; -.
DR   PATRIC; fig|272562.8.peg.2916; -.
DR   eggNOG; COG1387; Bacteria.
DR   HOGENOM; CLU_054611_3_0_9; -.
DR   OMA; THHSYDS; -.
DR   OrthoDB; 1615112at2; -.
DR   UniPathway; UPA00031; UER00013.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0004401; F:histidinol-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR010140; Histidinol_P_phosphatase_HisJ.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   PANTHER; PTHR21039; PTHR21039; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR01856; hisJ_fam; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Hydrolase;
KW   Reference proteome.
FT   CHAIN           1..255
FT                   /note="Probable histidinol-phosphatase"
FT                   /id="PRO_0000122317"
SQ   SEQUENCE   255 AA;  30085 MW;  F38015194FE9F5E6 CRC64;
     MVFDTHLHTL FSTDSKMNIE EAIDAGEKKN LGIIITEHID LNYPVKGEFV FDIDKYFKEY
     NKYRSNKVLL GVEIGMGEEI KEQNKSINDK YEFDYVLGSI HLLNGLDLYE KTIYKSSPKK
     EVFEMYFKTM LACLRCHEYI DSLAHIDYIS RYAAYHDGEI YYNEYSDYID EVLKFIVDRE
     IVIEINTRRL NKKEVCENLM PIYKRYSELG GRFVTIGSDS HYKDSIGLNF KNALKMAENC
     NLKPVFFEKR LMKYA