HIS9_LACLA
ID HIS9_LACLA Reviewed; 269 AA.
AC Q02150; Q9CG89;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2001, sequence version 2.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Histidinol-phosphatase;
DE Short=HolPase;
DE EC=3.1.3.15;
GN Name=hisK; OrderedLocusNames=LL1216; ORFNames=L37351;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCDO 2118;
RX PubMed=1400209; DOI=10.1128/jb.174.20.6571-6579.1992;
RA Delorme C., Ehrlich S.D., Renault P.;
RT "Histidine biosynthesis genes in Lactococcus lactis subsp. lactis.";
RL J. Bacteriol. 174:6571-6579(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate;
CC Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15;
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
CC -!- SIMILARITY: Belongs to the PHP hydrolase family. HisK subfamily.
CC {ECO:0000305}.
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DR EMBL; U92974; AAB81911.1; -; Genomic_DNA.
DR EMBL; AE005176; AAK05314.1; -; Genomic_DNA.
DR PIR; D47754; D47754.
DR PIR; H86776; H86776.
DR RefSeq; NP_267372.1; NC_002662.1.
DR RefSeq; WP_003131121.1; NC_002662.1.
DR PDB; 4GC3; X-ray; 1.32 A; A=2-269.
DR PDB; 4GK8; X-ray; 1.93 A; A=2-269.
DR PDB; 4GYF; X-ray; 1.65 A; A=2-269.
DR PDBsum; 4GC3; -.
DR PDBsum; 4GK8; -.
DR PDBsum; 4GYF; -.
DR AlphaFoldDB; Q02150; -.
DR SMR; Q02150; -.
DR STRING; 272623.L37351; -.
DR PaxDb; Q02150; -.
DR EnsemblBacteria; AAK05314; AAK05314; L37351.
DR KEGG; lla:L37351; -.
DR PATRIC; fig|272623.7.peg.1313; -.
DR eggNOG; COG1387; Bacteria.
DR HOGENOM; CLU_054611_3_0_9; -.
DR OMA; DYDRPMY; -.
DR BRENDA; 3.1.3.15; 2864.
DR UniPathway; UPA00031; UER00013.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0004401; F:histidinol-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010140; Histidinol_P_phosphatase_HisJ.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR PANTHER; PTHR21039; PTHR21039; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; SSF89550; 1.
DR TIGRFAMs; TIGR01856; hisJ_fam; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Amino-acid biosynthesis; Histidine biosynthesis; Hydrolase;
KW Reference proteome.
FT CHAIN 1..269
FT /note="Histidinol-phosphatase"
FT /id="PRO_0000122319"
FT CONFLICT 25
FT /note="T -> I (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="H -> Y (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT CONFLICT 71..73
FT /note="KIK -> EIN (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="I -> T (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT CONFLICT 146
FT /note="N -> T (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="K -> T (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="E -> G (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="E -> G (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT CONFLICT 215
FT /note="K -> R (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT CONFLICT 250
FT /note="H -> R (in Ref. 1; AAB81911)"
FT /evidence="ECO:0000305"
FT HELIX 20..29
FT /evidence="ECO:0007829|PDB:4GC3"
FT STRAND 33..42
FT /evidence="ECO:0007829|PDB:4GC3"
FT HELIX 54..67
FT /evidence="ECO:0007829|PDB:4GC3"
FT TURN 68..71
FT /evidence="ECO:0007829|PDB:4GC3"
FT STRAND 73..81
FT /evidence="ECO:0007829|PDB:4GC3"
FT HELIX 84..86
FT /evidence="ECO:0007829|PDB:4GC3"
FT HELIX 87..94
FT /evidence="ECO:0007829|PDB:4GC3"
FT STRAND 100..105
FT /evidence="ECO:0007829|PDB:4GC3"
FT HELIX 119..121
FT /evidence="ECO:0007829|PDB:4GC3"
FT HELIX 126..143
FT /evidence="ECO:0007829|PDB:4GC3"
FT STRAND 148..150
FT /evidence="ECO:0007829|PDB:4GC3"
FT HELIX 155..158
FT /evidence="ECO:0007829|PDB:4GC3"
FT STRAND 159..161
FT /evidence="ECO:0007829|PDB:4GYF"
FT HELIX 170..172
FT /evidence="ECO:0007829|PDB:4GC3"
FT HELIX 173..185
FT /evidence="ECO:0007829|PDB:4GC3"
FT STRAND 189..193
FT /evidence="ECO:0007829|PDB:4GC3"
FT TURN 195..198
FT /evidence="ECO:0007829|PDB:4GC3"
FT HELIX 200..215
FT /evidence="ECO:0007829|PDB:4GC3"
FT STRAND 220..224
FT /evidence="ECO:0007829|PDB:4GC3"
FT STRAND 228..230
FT /evidence="ECO:0007829|PDB:4GC3"
FT HELIX 234..246
FT /evidence="ECO:0007829|PDB:4GC3"
SQ SEQUENCE 269 AA; 31473 MW; CF51601DEDD5B8C2 CRC64;
MKKLDYHFHS HFSADSEELP RKHVTEAIAH GLEEICFTEH RDFYFPGMDF SLNLPEYFQE
INRLQAEFKD KIKIKIGLEM GIDLRFKSEI NQFIDSAPFD FVIASVHEIG DIEVYDGTEF
YLQKIKEEAQ REYLLACLDV VQNFENYNSF GHLDYVARYG PYTDKSIKFA ENREILFEIL
RALASKEKAL EINTRLFDDP KTEQFYSDLL INFKKLGGKF ITLGTDSHIA KRDWLSIHKA
RTLIKKAGFH ELATFSGMKI DKNKKSIKE
