ID   HIS9_SCHPO              Reviewed;         306 AA.
AC   O14059;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Probable histidinol-phosphatase;
DE            Short=HolPase;
DE            EC=3.1.3.15;
GN   ORFNames=SPCC1672.01;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate;
CC         Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
CC   -!- SIMILARITY: Belongs to the PHP hydrolase family. HisK subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CU329672; CAA20439.1; -; Genomic_DNA.
DR   PIR; T41045; T41045.
DR   RefSeq; NP_587872.3; NM_001022864.3.
DR   AlphaFoldDB; O14059; -.
DR   SMR; O14059; -.
DR   STRING; 4896.SPCC1672.01.1; -.
DR   iPTMnet; O14059; -.
DR   MaxQB; O14059; -.
DR   PaxDb; O14059; -.
DR   EnsemblFungi; SPCC1672.01.1; SPCC1672.01.1:pep; SPCC1672.01.
DR   PomBase; SPCC1672.01; -.
DR   VEuPathDB; FungiDB:SPCC1672.01; -.
DR   eggNOG; ENOG502RXUQ; Eukaryota.
DR   HOGENOM; CLU_054611_0_0_1; -.
DR   InParanoid; O14059; -.
DR   OMA; DYDRPMY; -.
DR   PhylomeDB; O14059; -.
DR   UniPathway; UPA00031; UER00013.
DR   PRO; PR:O14059; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0004401; F:histidinol-phosphatase activity; ISO:PomBase.
DR   GO; GO:0000105; P:histidine biosynthetic process; ISO:PomBase.
DR   InterPro; IPR010140; Histidinol_P_phosphatase_HisJ.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   PANTHER; PTHR21039; PTHR21039; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR01856; hisJ_fam; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Hydrolase;
KW   Reference proteome.
FT   CHAIN           1..306
FT                   /note="Probable histidinol-phosphatase"
FT                   /id="PRO_0000122321"
SQ   SEQUENCE   306 AA;  35050 MW;  03973248225364EC CRC64;
     MPISSHSHSG QFCLHAQGKL EDVIQEAIQQ GFQSFSFTEH TPRDRVEDLY PEELHLQPED
     LFKTFDEYVN EARRLKQNYG DQINILIGAE TEYIRPESVE LLKSLNTKYN LDYFVGSVHH
     VNSIPIDFSP ELWQKALQHV GNNPEQLFID YFEHQYDLMQ RLHPLVIGHF DLICLFAPED
     AKEVFKNSKS VWELIQRNIK YAVSYGGIFE INTSAFRKGW KTAYPQQRLL ELMVEQGAQL
     TLSDDSHGPH QVGLNYHLAK SYLDKCGITS LCMIEKGPDG NGTVVKNVTV DNVWSKFVGT
     NGITNT