ID   HIS9_THEMA              Reviewed;         233 AA.
AC   Q9WZR1;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Probable histidinol-phosphatase;
DE            Short=HolPase;
DE            EC=3.1.3.15;
GN   Name=hisK; OrderedLocusNames=TM_0804;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate;
CC         Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
CC   -!- SIMILARITY: Belongs to the PHP hydrolase family. HisK subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000512; AAD35886.1; -; Genomic_DNA.
DR   PIR; E72330; E72330.
DR   RefSeq; NP_228613.1; NC_000853.1.
DR   RefSeq; WP_004080859.1; NZ_CP011107.1.
DR   AlphaFoldDB; Q9WZR1; -.
DR   SMR; Q9WZR1; -.
DR   STRING; 243274.THEMA_00630; -.
DR   EnsemblBacteria; AAD35886; AAD35886; TM_0804.
DR   KEGG; tma:TM0804; -.
DR   eggNOG; COG1387; Bacteria.
DR   InParanoid; Q9WZR1; -.
DR   OMA; THHSYDS; -.
DR   OrthoDB; 1615112at2; -.
DR   UniPathway; UPA00031; UER00013.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0004401; F:histidinol-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0000105; P:histidine biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR010140; Histidinol_P_phosphatase_HisJ.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   PANTHER; PTHR21039; PTHR21039; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Hydrolase;
KW   Reference proteome.
FT   CHAIN           1..233
FT                   /note="Probable histidinol-phosphatase"
FT                   /id="PRO_0000122320"
SQ   SEQUENCE   233 AA;  27144 MW;  E0CE3D245E0EDA30 CRC64;
     MIDMHLHSTF SYDGKAEIDD IISQVQKLGI EHFCITDHYE YENGELVHDF NVEEYFLTME
     KYDLPKGAEI SWDGVGEAVF PDGFDYLLLG IHRYDENLPP DELARDYLER TLFVMERVKF
     HTLAHLDYPA RYAKADFKAN RDLIEKILVF LVKNEKALEI NTAGLFKHGK PNPDYWIVEM
     YYDLGGRVVT IGSDAHESQH IGRGIEEVMR ELKKFNFEYL AVDGKKLVTV KLR