HIS9_YEAST
ID HIS9_YEAST Reviewed; 335 AA.
AC P38635; D6VTQ5;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Histidinol-phosphatase;
DE Short=HolPase;
DE EC=3.1.3.15;
GN Name=HIS2; OrderedLocusNames=YFR025C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8056323; DOI=10.1093/genetics/137.1.5;
RA Malone R.E., Kim S., Bullard S.A., Lundquist S., Hutchings-Crow L.,
RA Cramton S., Lutfiyya L., Lee J.;
RT "Analysis of a recombination hotspot for gene conversion occurring at the
RT HIS2 gene of Saccharomyces cerevisiae.";
RL Genetics 137:5-18(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=8686381;
RX DOI=10.1002/(sici)1097-0061(199602)12:2<177::aid-yea896>3.0.co;2-a;
RA Eki T., Naitou M., Hagiwara H., Abe M., Ozawa M., Sasanuma S., Sasanuma M.,
RA Tsuchiya Y., Shibata T., Watanabe K., Ono A., Yamazaki M., Tashiro H.,
RA Hanaoka F., Murakami Y.;
RT "Fifteen open reading frames in a 30.8 kb region of the right arm of
RT chromosome VI from Saccharomyces cerevisiae.";
RL Yeast 12:177-190(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate;
CC Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15;
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
CC -!- MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the PHP hydrolase family. HisK subfamily.
CC {ECO:0000305}.
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DR EMBL; U09479; AAA18399.1; -; Unassigned_DNA.
DR EMBL; D50617; BAA09264.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12465.1; -; Genomic_DNA.
DR PIR; S56280; S56280.
DR RefSeq; NP_116681.1; NM_001179990.1.
DR AlphaFoldDB; P38635; -.
DR SMR; P38635; -.
DR BioGRID; 31178; 10.
DR IntAct; P38635; 2.
DR MINT; P38635; -.
DR STRING; 4932.YFR025C; -.
DR MaxQB; P38635; -.
DR PaxDb; P38635; -.
DR PRIDE; P38635; -.
DR EnsemblFungi; YFR025C_mRNA; YFR025C; YFR025C.
DR GeneID; 850581; -.
DR KEGG; sce:YFR025C; -.
DR SGD; S000001921; HIS2.
DR VEuPathDB; FungiDB:YFR025C; -.
DR eggNOG; ENOG502RXUQ; Eukaryota.
DR HOGENOM; CLU_054611_0_1_1; -.
DR InParanoid; P38635; -.
DR OMA; DYDRPMY; -.
DR BioCyc; YEAST:YFR025C-MON; -.
DR UniPathway; UPA00031; UER00013.
DR PRO; PR:P38635; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P38635; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0004401; F:histidinol-phosphatase activity; IMP:SGD.
DR GO; GO:0000105; P:histidine biosynthetic process; IMP:SGD.
DR InterPro; IPR010140; Histidinol_P_phosphatase_HisJ.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR PANTHER; PTHR21039; PTHR21039; 1.
DR Pfam; PF02811; PHP; 1.
DR SUPFAM; SSF89550; SSF89550; 1.
DR TIGRFAMs; TIGR01856; hisJ_fam; 1.
PE 1: Evidence at protein level;
KW Amino-acid biosynthesis; Histidine biosynthesis; Hydrolase;
KW Reference proteome.
FT CHAIN 1..335
FT /note="Histidinol-phosphatase"
FT /id="PRO_0000122322"
FT CONFLICT 30
FT /note="N -> H (in Ref. 1; AAA18399)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="D -> H (in Ref. 1; AAA18399)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="N -> H (in Ref. 1; AAA18399)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 38582 MW; 2F99522F26339DCB CRC64;
MHSHHSHSGD YSAHGTDPLD SVVDQVVNLN FHTYCLTEHI PRIEAKFIYP EEQSLGKNPE
EVITKLETSF KNFMSHAQEI KTRYADRPDV RTKFIIGMEI ESCDMAHIEY AKRLMKENND
ILKFCVGSVH HVNGIPIDFD QQQWYNSLHS FNDNLKHFLL SYFQSQYEML INIKPLVVGH
FDLYKLFLPN DMLVNQKSGN CNEETGVPVA SLDVISEWPE IYDAVVRNLQ FIDSYGGAIE
INTSALRKRL EEPYPSKTLC NLVKKHCGSR FVLSDDAHGV AQVGVCYDKV KKYIVDVLQL
EYICYLEESQ SPENLLTVKR LPISQFVNDP FWANI
