ID   HISAT_XENTR             Reviewed;         324 AA.
AC   Q0P4Y1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Histidine N-acetyltransferase;
DE            EC=2.3.1.33 {ECO:0000250|UniProtKB:I3J7Q8};
GN   Name=hisat; Synonyms=nat16;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enzyme responsible for the N-acetyl-histidine (NAH)
CC       synthesis, which is a major constituent of brain and lens of
CC       ectothermic vertebrates. {ECO:0000250|UniProtKB:I3J7Q8}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-histidine = CoA + H(+) + N(alpha)-acetyl-L-
CC         histidine; Xref=Rhea:RHEA:24596, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57595,
CC         ChEBI:CHEBI:57772; EC=2.3.1.33;
CC         Evidence={ECO:0000250|UniProtKB:I3J7Q8};
CC   -!- MISCELLANEOUS: Strong histidine N-acetyltransferase activity has been
CC       detected in ectothermic vertebrates and not in endothermic birds and
CC       mammals. {ECO:0000250|UniProtKB:Q8N8M0}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC121852; AAI21853.1; -; mRNA.
DR   RefSeq; NP_001072454.1; NM_001078986.1.
DR   RefSeq; XP_012808828.1; XM_012953374.2.
DR   RefSeq; XP_012808829.1; XM_012953375.2.
DR   AlphaFoldDB; Q0P4Y1; -.
DR   SMR; Q0P4Y1; -.
DR   STRING; 8364.ENSXETP00000008705; -.
DR   PaxDb; Q0P4Y1; -.
DR   DNASU; 779909; -.
DR   Ensembl; ENSXETT00000008705; ENSXETP00000008705; ENSXETG00000004015.
DR   GeneID; 779909; -.
DR   KEGG; xtr:779909; -.
DR   CTD; 375607; -.
DR   Xenbase; XB-GENE-5881951; nat16.
DR   eggNOG; ENOG502QW73; Eukaryota.
DR   HOGENOM; CLU_074598_0_0_1; -.
DR   InParanoid; Q0P4Y1; -.
DR   OMA; SWLQETN; -.
DR   OrthoDB; 1293735at2759; -.
DR   PhylomeDB; Q0P4Y1; -.
DR   TreeFam; TF331490; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004015; Expressed in brain and 2 other tissues.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR   GO; GO:0047981; F:histidine N-acetyltransferase activity; ISS:UniProtKB.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..324
FT                   /note="Histidine N-acetyltransferase"
FT                   /id="PRO_0000309190"
FT   DOMAIN          15..151
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   324 AA;  36276 MW;  05502E6E4EA9402D CRC64;
     MKIEAVPGAP QDGEFEFVLA AEKEFEEIIS ISHGIYGGLD YLPSRYHSWI NEKDRMVVLA
     KKDGTVIGLL SVFVVDGGET ALLEGLRVAP WERGRGVAGV LQRFCIKLVK HRYPSVKVMR
     LTRDDKLSAK ELTKYRVIAK QGILLLSFNA PDLASRLSSI PLPPAASRPP PPIELTPEDV
     RDVFLERGGL LKDLLPNQTI IQDWQPFQAL PGNQDLLRRK TLCWMVDDLI QPQVATLCTA
     PFPVPAGPLC FYLNIDVFGS ELQSVQEQLL SHLHAHVPKL PADVRCQLFL PPNLWRPMAD
     FCTLVLGLHL EKGYTEQYLL EADI