HISJ_CAMJE
ID HISJ_CAMJE Reviewed; 256 AA.
AC Q46125; Q0PAE5; Q9PPH3;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Probable histidine-binding protein;
DE Short=HBP;
DE AltName: Full=p29;
DE Flags: Precursor;
GN Name=hisJ; Synonyms=cjaC; OrderedLocusNames=Cj0734c;
OS Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS 11168).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=192222;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN HISTIDINE TRANSPORT.
RC STRAIN=M275;
RX PubMed=8751896; DOI=10.1128/iai.64.9.3537-3543.1996;
RA Garvis S.G., Puzon G.J., Konkel M.E.;
RT "Molecular characterization of a Campylobacter jejuni 29-kilodalton
RT periplasmic binding protein.";
RL Infect. Immun. 64:3537-3543(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=M275;
RX PubMed=9192026; DOI=10.1007/978-1-4899-1828-4_42;
RA Garvis S.G., Puzon G.J., Konkel M.E.;
RT "Cloning, sequencing, and expression of a Campylobacter jejuni periplasmic
RT binding protein (P29) involved in histidine transport.";
RL Adv. Exp. Med. Biol. 412:263-264(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=72Dz/92;
RX PubMed=9395059; DOI=10.1111/j.1574-695x.1997.tb01083.x;
RA Pawelec D., Rozynek E., Popowski J., Jagusztyn-Krynicka E.K.;
RT "Cloning and characterization of a Campylobacter jejuni 72Dz/92 gene
RT encoding a 30 kDa immunopositive protein, component of the ABC transport
RT system; expression of the gene in avirulent Salmonella typhimurium.";
RL FEMS Immunol. Med. Microbiol. 19:137-150(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700819 / NCTC 11168;
RX PubMed=10688204; DOI=10.1038/35001088;
RA Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA Barrell B.G.;
RT "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT reveals hypervariable sequences.";
RL Nature 403:665-668(2000).
CC -!- FUNCTION: Involved in histidine transport.
CC {ECO:0000269|PubMed:8751896}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}. Note=Periplasmic when expressed in E.coli.
CC {ECO:0000269|PubMed:8751896}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 3 family.
CC {ECO:0000305}.
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DR EMBL; U58045; AAC35419.1; -; Genomic_DNA.
DR EMBL; Y10873; CAA71823.1; -; Genomic_DNA.
DR EMBL; AL111168; CAL34871.1; -; Genomic_DNA.
DR PIR; A81345; A81345.
DR RefSeq; YP_002344152.1; NC_002163.1.
DR AlphaFoldDB; Q46125; -.
DR SMR; Q46125; -.
DR IntAct; Q46125; 16.
DR PRIDE; Q46125; -.
DR EnsemblBacteria; CAL34871; CAL34871; Cj0734c.
DR GeneID; 905052; -.
DR KEGG; cje:Cj0734c; -.
DR PATRIC; fig|192222.6.peg.726; -.
DR HOGENOM; CLU_019602_18_2_7; -.
DR Proteomes; UP000000799; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR018313; SBP_3_CS.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR Pfam; PF00497; SBP_bac_3; 1.
DR SMART; SM00062; PBPb; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS01039; SBP_BACTERIAL_3; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW Reference proteome; Signal; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 20..256
FT /note="Probable histidine-binding protein"
FT /id="PRO_0000031764"
FT LIPID 20
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 20
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
FT CONFLICT 4..8
FT /note="FLTAF -> ILSIA (in Ref. 4; CAL34871)"
FT /evidence="ECO:0000305"
FT CONFLICT 12..13
FT /note="FT -> LV (in Ref. 4; CAL34871)"
FT /evidence="ECO:0000305"
FT CONFLICT 18..38
FT /note="VACQNTKTENNASNEANTTLT -> GACSDSKNKESNASVE (in Ref.
FT 4; CAL34871)"
FT /evidence="ECO:0000305"
FT CONFLICT 52..55
FT /note="FKQD -> YKEN (in Ref. 4; CAL34871)"
FT /evidence="ECO:0000305"
FT CONFLICT 66
FT /note="I -> V (in Ref. 4; CAL34871)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="E -> K (in Ref. 4; CAL34871)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="S -> A (in Ref. 4; CAL34871)"
FT /evidence="ECO:0000305"
FT CONFLICT 228
FT /note="D -> N (in Ref. 4; CAL34871)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 256 AA; 28531 MW; 2E3E34DFCB92CB29 CRC64;
MKKFLTAFLV AFTGLFLVAC QNTKTENNAS NEANTTLTLK VGTAPNYKPF NFKQDSKLTG
FDTDLIEEIA KKNGIEIVWV ETNFDGLIPA LKSGKIDMIA SAMSATDERR QSVDFTKPYY
MSKNLYLKLK NNDSLQTKND LEGKKIGVQL GTLQENTAKA IKNAQVQSNK DLNIAVLALK
NNKIDAIVAD QDTAKGFLAE NPELVSFYQE TDGGEGFSFA FDKNKQKDII EIFNKGIDEA
KTDGFYDTLI KKYELE
