ID   HISJ_NEIGO              Reviewed;         268 AA.
AC   Q06758;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Probable histidine-binding protein;
DE            Short=HBP;
DE   Flags: Precursor;
GN   Name=hisJ;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=T2;
RX   PubMed=1448614; DOI=10.1016/0923-2508(92)90021-f;
RA   Lavitola A., Vanni M., Martin P.M.V., Bruni C.B.;
RT   "Cloning and characterization of a Neisseria gene homologous to hisJ and
RT   argT of Escherichia coli and Salmonella typhimurium.";
RL   Res. Microbiol. 143:295-305(1992).
CC   -!- FUNCTION: Involved in histidine transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 3 family.
CC       {ECO:0000305}.
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DR   EMBL; X64421; CAA45768.1; -; Genomic_DNA.
DR   PIR; S19184; S19184.
DR   RefSeq; WP_003691772.1; NZ_UGRL01000001.1.
DR   AlphaFoldDB; Q06758; -.
DR   SMR; Q06758; -.
DR   GeneID; 66753866; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015276; F:ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001320; Iontro_rcpt.
DR   InterPro; IPR018313; SBP_3_CS.
DR   InterPro; IPR001638; Solute-binding_3/MltF_N.
DR   Pfam; PF00497; SBP_bac_3; 1.
DR   SMART; SM00062; PBPb; 1.
DR   SMART; SM00079; PBPe; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS01039; SBP_BACTERIAL_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW   Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           21..268
FT                   /note="Probable histidine-binding protein"
FT                   /id="PRO_0000031765"
FT   LIPID           21
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           21
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   268 AA;  28859 MW;  52F9BD24583559D8 CRC64;
     MNMKKWIAAA LACSALALSA CGGQGKDAAA PAANPGKVYR VASNAEFAPF ESLDSKGNVE
     GFDVDLMNAM AKAGNFKIEF KHQPWDSLFP ALNNGDADIV MSGVTITDDR KQSMDFSDPY
     FEITQVVLVP KGKKVSSSDD LKKMNKVGVV TGHTGDFSVS KLLGNDNPKI ARFENVPLII
     KELENGGLDS VVSDSAVIAN YVKNNPAKGM DFVTLPDFTT EHYGIAVRKG DEATVKMLND
     ALEKVRESGE YDKIYAKYFA KEGGQAAK