ID   HISP_ECOLI              Reviewed;         257 AA.
AC   P07109; P77299;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 165.
DE   RecName: Full=Histidine transport ATP-binding protein HisP;
GN   Name=hisP; OrderedLocusNames=b2306, JW2303;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=3313284; DOI=10.1093/nar/15.20.8568;
RA   Kraft R., Leinwand L.A.;
RT   "Sequence of the complete P protein gene and part of the M protein gene
RT   from the histidine transport operon of Escherichia coli compared to that of
RT   Salmonella typhimurium.";
RL   Nucleic Acids Res. 15:8568-8568(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA   Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA   Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA   Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT   genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT   its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   PROTEIN SEQUENCE OF 15-22 AND 30-44.
RX   PubMed=2246240; DOI=10.1016/s0021-9258(17)45405-6;
RA   Mimura C.S., Admon A., Hurt K.A., Ames G.F.-L.;
RT   "The nucleotide-binding site of HisP, a membrane protein of the histidine
RT   permease. Identification of amino acid residues photoaffinity labeled by 8-
RT   azido-ATP.";
RL   J. Biol. Chem. 265:19535-19542(1990).
RN   [6]
RP   IDENTIFICATION BY 2D-GEL.
RX   PubMed=9298644; DOI=10.1002/elps.1150180805;
RA   VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.;
RT   "Escherichia coli proteome analysis using the gene-protein database.";
RL   Electrophoresis 18:1243-1251(1997).
CC   -!- FUNCTION: Part of the histidine permease ABC transporter. Also part of
CC       a lysine/arginine/ornithine transporter. Responsible for energy
CC       coupling to the transport system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HisP),
CC       two transmembrane proteins (HisM and HisQ) and a solute-binding protein
CC       (HisJ or ArgT). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; Y00455; CAA68511.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75366.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16143.1; -; Genomic_DNA.
DR   PIR; H65002; H65002.
DR   RefSeq; NP_416809.1; NC_000913.3.
DR   RefSeq; WP_001293613.1; NZ_LN832404.1.
DR   AlphaFoldDB; P07109; -.
DR   SMR; P07109; -.
DR   BioGRID; 4263202; 13.
DR   BioGRID; 851130; 2.
DR   ComplexPortal; CPX-4328; Histidine ABC transporter complex.
DR   ComplexPortal; CPX-4329; Polar amino acid ABC transporter complex.
DR   IntAct; P07109; 5.
DR   STRING; 511145.b2306; -.
DR   TCDB; 3.A.1.3.29; the atp-binding cassette (abc) superfamily.
DR   jPOST; P07109; -.
DR   PaxDb; P07109; -.
DR   PRIDE; P07109; -.
DR   EnsemblBacteria; AAC75366; AAC75366; b2306.
DR   EnsemblBacteria; BAA16143; BAA16143; BAA16143.
DR   GeneID; 946789; -.
DR   KEGG; ecj:JW2303; -.
DR   KEGG; eco:b2306; -.
DR   PATRIC; fig|1411691.4.peg.4428; -.
DR   EchoBASE; EB0447; -.
DR   eggNOG; COG4598; Bacteria.
DR   HOGENOM; CLU_000604_1_22_6; -.
DR   InParanoid; P07109; -.
DR   OMA; EVFCLIG; -.
DR   PhylomeDB; P07109; -.
DR   BioCyc; EcoCyc:HISP-MON; -.
DR   PRO; PR:P07109; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR   GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR   GO; GO:0015424; F:ABC-type amino acid transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; ISM:EcoCyc.
DR   GO; GO:0005291; F:high-affinity L-histidine transmembrane transporter activity; TAS:EcoCyc.
DR   GO; GO:0089718; P:amino acid import across plasma membrane; IC:ComplexPortal.
DR   GO; GO:1903810; P:L-histidine import across plasma membrane; TAS:EcoCyc.
DR   GO; GO:0089709; P:L-histidine transmembrane transport; TAS:EcoCyc.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR030679; ABC_ATPase_HisP-typ.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   PIRSF; PIRSF039085; ABC_ATPase_HisP; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; ATP-binding; Cell inner membrane; Cell membrane;
KW   Direct protein sequencing; Membrane; Nucleotide-binding;
KW   Reference proteome; Transport.
FT   CHAIN           1..257
FT                   /note="Histidine transport ATP-binding protein HisP"
FT                   /id="PRO_0000092341"
FT   DOMAIN          6..252
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         38..45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CONFLICT        17
FT                   /note="E -> G (in Ref. 5; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        191
FT                   /note="V -> L (in Ref. 1; CAA68511)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   257 AA;  28653 MW;  5D2F598F2F757291 CRC64;
     MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC INFLEKPSEG
     SIVVNGQTIN LVRDKDGQLK VADKNQLRLL RTRLTMVFQH FNLWSHMTVL ENVMEAPIQV
     LGLSKQEARE RAVKYLAKVG IDERAQGKYP VHLSGGQQQR VSIARALAME PEVLLFDEPT
     SALDPELVGE VLRIMQQLAE EGKTMVVVTH EMGFARHVST HVIFLHQGKI EEEGAPEQLF
     GNPQSPRLQR FLKGSLK