ID   HISP_LACLM              Reviewed;         477 AA.
AC   A2RI97;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Histidine permease HisP {ECO:0000305};
GN   Name=hisP {ECO:0000303|PubMed:23144255};
GN   Synonyms=lysQ {ECO:0000312|EMBL:CAL96991.1};
GN   OrderedLocusNames=llmg_0386 {ECO:0000312|EMBL:CAL96991.1};
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=MG1363;
RX   PubMed=23144255; DOI=10.1128/jb.01948-12;
RA   Trip H., Mulder N.L., Lolkema J.S.;
RT   "Cloning, expression, and functional characterization of secondary amino
RT   acid transporters of Lactococcus lactis.";
RL   J. Bacteriol. 195:340-350(2013).
CC   -!- FUNCTION: Involved in histidine uptake. Has low affinity for arginine
CC       and lysine. Plays no significant role in the excretion of accumulated
CC       histidine. {ECO:0000269|PubMed:23144255}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the gene leads to strong reduction of
CC       histidine uptake. {ECO:0000269|PubMed:23144255}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC       {ECO:0000305}.
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DR   EMBL; AM406671; CAL96991.1; -; Genomic_DNA.
DR   RefSeq; WP_011834439.1; NZ_WJVF01000001.1.
DR   AlphaFoldDB; A2RI97; -.
DR   SMR; A2RI97; -.
DR   STRING; 416870.llmg_0386; -.
DR   EnsemblBacteria; CAL96991; CAL96991; llmg_0386.
DR   KEGG; llm:llmg_0386; -.
DR   eggNOG; COG0833; Bacteria.
DR   HOGENOM; CLU_007946_9_2_9; -.
DR   OMA; NSDMYIC; -.
DR   PhylomeDB; A2RI97; -.
DR   BioCyc; LLAC416870:LLMG_RS01980-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   Pfam; PF00324; AA_permease; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..477
FT                   /note="Histidine permease HisP"
FT                   /id="PRO_0000442540"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   477 AA;  51946 MW;  9EB20BBA497FCD1C CRC64;
     MENQNQVKRN LKQRHITMIA LGGTIGTGLF LTSGATISQA GPWGAVLAYC FIGIMVYFVM
     TSLGEMATYL PTSGSFSDYG GRYVDPAFGF ALGWNYWLNG AITIAVDLTT AGLITQFWFP
     HLPSWIFSGI ATVLIFIINV MAVGAFGETE YWLSTIKVIT IVLFLAIGLL TIFGVLGQGN
     VDVVANLTAG NHGFVGGISG FVGVLLIAGF SFQGTEMLGI TAGESEDPGK TIPKAMNSIF
     WRILLFYIFS IIVIAAIINF KDPRLLNPSS TAVMSPFTIV FKNIGFAVAA SVMNAVILTS
     VISSANSVMY ASTRILYSLG QEKGAPKFFG RTAKNGIPFY ALLATTIICF IAFLTGIFGT
     QIYLFLIDLS SLTGFLAWLG ISVSHIRFRR AYIAQGKKLE DLPYKAKWFP FGPIVALLMT
     GAIAINLDPA MLFSEHWGEG LALYAAIPIF IVLYFGYKWK YNTKIIPLEE VDLSREK