ID   HISXH_SYNY3             Reviewed;         409 AA.
AC   P72946;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Histidinol dehydrogenase homolog {ECO:0000305};
DE            EC=1.1.-.- {ECO:0000305};
GN   OrderedLocusNames=slr0682;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- SIMILARITY: Belongs to the histidinol dehydrogenase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could lack activity as the potential active sites and zinc-
CC       binding sites are missing. {ECO:0000305}.
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DR   EMBL; BA000022; BAA16963.1; -; Genomic_DNA.
DR   PIR; S74923; S74923.
DR   AlphaFoldDB; P72946; -.
DR   SMR; P72946; -.
DR   STRING; 1148.1652038; -.
DR   PaxDb; P72946; -.
DR   EnsemblBacteria; BAA16963; BAA16963; BAA16963.
DR   KEGG; syn:slr0682; -.
DR   eggNOG; COG0141; Bacteria.
DR   OMA; MTDRDDW; -.
DR   PhylomeDB; P72946; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004399; F:histidinol dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0000105; P:histidine biosynthetic process; IBA:GO_Central.
DR   CDD; cd06572; Histidinol_dh; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR022695; Histidinol_DH_monofunct.
DR   InterPro; IPR012131; Hstdl_DH.
DR   PANTHER; PTHR21256; PTHR21256; 1.
DR   Pfam; PF00815; Histidinol_dh; 1.
DR   PIRSF; PIRSF000099; Histidinol_dh; 1.
DR   PRINTS; PR00083; HOLDHDRGNASE.
DR   SUPFAM; SSF53720; SSF53720; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..409
FT                   /note="Histidinol dehydrogenase homolog"
FT                   /id="PRO_0000135866"
SQ   SEQUENCE   409 AA;  45138 MW;  2EC7B208A7C67073 CRC64;
     MLRLITQSGD IVQELRRLHH RPVPSPWPVM AQVVAAMEHW AAMDQDAPPR VSGAELDAAY
     QRISQEKLSV IRQACAALEQ VYRPQLPKTQ VSFPEDGTVR GQRFYPVRRA GFYLEAKRGD
     ALGNLLRQGM LAKTVGVAER VLVTETISST ILVAAQEMGI EEIYLAAGVP AIAMLTWGAK
     NIAPVESITG AGCPRVMAAK QLVSGVVTID QTLARTNLMV LADGEANGQW LALDLLAHAE
     QYPNASAVLL TDRLELGEEV IQSVNRYCRE QEHSVHTEKA LAHYGLVAIV EDLEACGSWI
     NEFCPHILLL AMEDPWTMVE KVQRAREIYI GHRSPSILGH YLSGANRLQT QDGAMATASE
     LAFHCFLRSS QLLDYGNNPP PPWLKDLVNW QGLTAIEERL GQLGRLKES