ID   HISX_AZOBR              Reviewed;         128 AA.
AC   P18786;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Putative histidinol dehydrogenase;
DE            Short=HDH;
DE            EC=1.1.1.23;
DE   Flags: Fragment;
GN   Name=hisD;
OS   Azospirillum brasilense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Azospirillaceae; Azospirillum.
OX   NCBI_TaxID=192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sp6;
RX   PubMed=2664449; DOI=10.1007/bf00334360;
RA   Fani R., Bazzicalupo M., Damiani G., Bianchi A., Schipani C.,
RA   Sgaramella V., Polsinelli M.;
RT   "Cloning of histidine genes of Azospirillum brasilense: organization of the
RT   ABFH gene cluster and nucleotide sequence of the hisB gene.";
RL   Mol. Gen. Genet. 216:224-229(1989).
CC   -!- FUNCTION: Catalyzes the sequential NAD-dependent oxidations of L-
CC       histidinol to L-histidinaldehyde and then to L-histidine.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH;
CC         Xref=Rhea:RHEA:20641, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57595, ChEBI:CHEBI:57699,
CC         ChEBI:CHEBI:57945; EC=1.1.1.23;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
CC   -!- SIMILARITY: Belongs to the histidinol dehydrogenase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Highly divergent compared to other bacterial HisD.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X17435; CAA35477.1; -; Genomic_DNA.
DR   PIR; PE0006; PE0006.
DR   AlphaFoldDB; P18786; -.
DR   UniPathway; UPA00031; UER00014.
DR   GO; GO:0004399; F:histidinol dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; NAD; Oxidoreductase.
FT   CHAIN           <1..128
FT                   /note="Putative histidinol dehydrogenase"
FT                   /id="PRO_0000135719"
FT   REGION          21..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   128 AA;  14111 MW;  BDF52031D2B04CCD CRC64;
     ILVQTAPAGP IDVLIGRPAL QRPDIAPRHH APPHRAEREA VEADRSRRTA GDGWGFAGLR
     QLPAHAGGQH QQGREGQEKA SGRRHVRCHI PLCALSVHTT MHTHALSGIA TDGHRRFRRR
     HLCRPRAS