3SOF3_NAJAT
ID 3SOF3_NAJAT Reviewed; 82 AA.
AC Q8UUK0;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Cytotoxin homolog Clbp-3;
DE AltName: Full=Cardiotoxin-like basic protein 3;
DE Short=CLBP3;
DE Flags: Precursor;
OS Naja atra (Chinese cobra).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX NCBI_TaxID=8656;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=15587986; DOI=10.1023/b:bigi.0000043955.35906.c2;
RA Chang L.-S., Lin S.-K., Chung C.;
RT "Molecular cloning and evolution of the genes encoding the precursors of
RT taiwan cobra cardiotoxin and cardiotoxin-like basic protein.";
RL Biochem. Genet. 42:429-440(2004).
CC -!- FUNCTION: Has low cytotoxic activity. {ECO:0000250|UniProtKB:P14541}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P62375}. Target
CC cell membrane {ECO:0000250|UniProtKB:P62375}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC residue stands at position 52 (Pro-31 in standard classification).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. Orphan group XV sub-subfamily. {ECO:0000305}.
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DR EMBL; AJ312212; CAC85538.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8UUK0; -.
DR SMR; Q8UUK0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003572; Cytotoxin_Cobra.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PRINTS; PR00282; CYTOTOXIN.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Membrane; Secreted; Signal; Target cell membrane;
KW Target membrane; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..82
FT /note="Cytotoxin homolog Clbp-3"
FT /id="PRO_5000067495"
FT DISULFID 24..43
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 36..60
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 64..75
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 76..81
FT /evidence="ECO:0000250|UniProtKB:P60301"
SQ SEQUENCE 82 AA; 8900 MW; 4FB697591D1FF149 CRC64;
MKTLLLTLVV VTIVCLDLGY TRKCHNSPLS LVYQTCPIGQ NICFKINVKE APSIPVKRAC
AATCPKSSAL VKVVCCKTDK CN