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3SOF3_NAJAT
ID   3SOF3_NAJAT             Reviewed;          82 AA.
AC   Q8UUK0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Cytotoxin homolog Clbp-3;
DE   AltName: Full=Cardiotoxin-like basic protein 3;
DE            Short=CLBP3;
DE   Flags: Precursor;
OS   Naja atra (Chinese cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=15587986; DOI=10.1023/b:bigi.0000043955.35906.c2;
RA   Chang L.-S., Lin S.-K., Chung C.;
RT   "Molecular cloning and evolution of the genes encoding the precursors of
RT   taiwan cobra cardiotoxin and cardiotoxin-like basic protein.";
RL   Biochem. Genet. 42:429-440(2004).
CC   -!- FUNCTION: Has low cytotoxic activity. {ECO:0000250|UniProtKB:P14541}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P62375}. Target
CC       cell membrane {ECO:0000250|UniProtKB:P62375}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC       residue stands at position 52 (Pro-31 in standard classification).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group XV sub-subfamily. {ECO:0000305}.
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DR   EMBL; AJ312212; CAC85538.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8UUK0; -.
DR   SMR; Q8UUK0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003572; Cytotoxin_Cobra.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   PRINTS; PR00282; CYTOTOXIN.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Secreted; Signal; Target cell membrane;
KW   Target membrane; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..82
FT                   /note="Cytotoxin homolog Clbp-3"
FT                   /id="PRO_5000067495"
FT   DISULFID        24..43
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        36..60
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        64..75
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        76..81
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   82 AA;  8900 MW;  4FB697591D1FF149 CRC64;
     MKTLLLTLVV VTIVCLDLGY TRKCHNSPLS LVYQTCPIGQ NICFKINVKE APSIPVKRAC
     AATCPKSSAL VKVVCCKTDK CN
 
 
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