ID   ANTF_SARPE              Reviewed;          85 AA.
AC   Q08617;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Antifungal protein;
DE            Short=AFP;
DE   Flags: Precursor;
OS   Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Sarcophagidae; Sarcophaga; Boettcherisca.
OX   NCBI_TaxID=7386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 20-54.
RC   TISSUE=Fat body;
RX   PubMed=8505329; DOI=10.1016/s0021-9258(19)50307-6;
RA   Iijima R., Kurata S., Natori S.;
RT   "Purification, characterization, and cDNA cloning of an antifungal protein
RT   from the hemolymph of Sarcophaga peregrina (flesh fly) larvae.";
RL   J. Biol. Chem. 268:12055-12061(1993).
CC   -!- FUNCTION: This protein inhibits the growth of a variety of fungal
CC       species. The antifungal activity of this protein is enhanced by the
CC       presence of sarcotoxin IA.
CC   -!- SUBUNIT: Homodimer.
CC   -!- TISSUE SPECIFICITY: Hemolymph.
CC   -!- PTM: The N-terminus is blocked.
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DR   EMBL; D13797; BAA02954.1; -; mRNA.
DR   PIR; A45969; A45969.
DR   AlphaFoldDB; Q08617; -.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antimicrobial; Direct protein sequencing; Fungicide; Repeat; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..85
FT                   /note="Antifungal protein"
FT                   /id="PRO_0000020738"
FT   REPEAT          19..25
FT                   /note="1"
FT   REPEAT          67..73
FT                   /note="2"
FT   REGION          19..73
FT                   /note="2 X 7 AA repeats of Q-H-G-H-G-G-Q"
FT   REGION          22..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   85 AA;  9018 MW;  E381779F923FB69B CRC64;
     MVKLFVIVIL ALIAVAFGQH GHGGQDQHGY GHGQQAVYGK GHEGHGVNNL GQDGHGQHGY
     AHGHSDQHGH GGQHGQHDGY KNRGY