ID   ANTP_DROSU              Reviewed;         394 AA.
AC   Q24645;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Homeotic protein antennapedia;
GN   Name=Antp;
OS   Drosophila subobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7241;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H271;
RX   PubMed=1358753; DOI=10.1093/genetics/132.2.453;
RA   Hooper J.E., Perez-Alonso M., Bermingham J.R. Jr., Prout M., Rocklein B.A.,
RA   Wagenbach M., Edstroem J.E., De Frutos R., Scott M.P.;
RT   "Comparative studies of Drosophila Antennapedia genes.";
RL   Genetics 132:453-469(1992).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that regulates segmental identity in
CC       the mesothorax. Provides cells with specific positional identities on
CC       the anterior-posterior axis (By similarity).
CC       {ECO:0000250|UniProtKB:P02833}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family.
CC       {ECO:0000303|PubMed:1358753}.
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DR   EMBL; X60995; CAA43307.1; -; Genomic_DNA.
DR   EMBL; X62246; CAA43307.1; JOINED; Genomic_DNA.
DR   PIR; S26492; S26492.
DR   AlphaFoldDB; Q24645; -.
DR   BMRB; Q24645; -.
DR   SMR; Q24645; -.
DR   FlyBase; FBgn0012932; Dsub\Antp.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.
DR   GO; GO:0007384; P:specification of segmental identity, thorax; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Repeat.
FT   CHAIN           1..394
FT                   /note="Homeotic protein antennapedia"
FT                   /id="PRO_0000200260"
FT   DNA_BIND        313..372
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          44..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          368..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           299..304
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        71..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..299
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   394 AA;  44550 MW;  E45D2BBB9C01334B CRC64;
     MTMSTNNCES MTSYFTNSYM GADMHHGHYP GNGVTDLDAQ QMHHYSQNPN HQGNMPYPRF
     PPYDRMPYYN GQGMDQQQQQ HQGYSRPDSP SSQVGGVMPQ AQTNGLPTGG QLVAQQQQQQ
     PQQQSQTPQQ QQAQQPQQQQ QQLQQLPQVT QQVTHPQQQQ QQQQQQQQPV VYASCKLQAA
     VGVGLGMVPE GGSPPLVDQM TGHHMNAQMS LPHHMGHPQA QLGYTDVGVP DVTEVHQNHH
     NMGMYGQQQT GVPPVGAPPQ AMMHQGQGPP QMHQGHLPGQ HTPPSQNPNS QSSGMPSPLY
     PWMRSQFGKC QERKRGRQTY TRYQTLELEK EFHFNRYLTR RRRIEIAHAL CLTERQIKIW
     FQNRRMKWKK ENKTKGEPGS GGEGDEITPP NSPQ