HISZ_AGRRK
ID HISZ_AGRRK Reviewed; 372 AA.
AC B9J9Y2;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=ATP phosphoribosyltransferase regulatory subunit {ECO:0000255|HAMAP-Rule:MF_00125};
GN Name=hisZ {ECO:0000255|HAMAP-Rule:MF_00125}; OrderedLocusNames=Arad_1056;
OS Agrobacterium radiobacter (strain K84 / ATCC BAA-868).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC Agrobacterium tumefaciens complex.
OX NCBI_TaxID=311403;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K84 / ATCC BAA-868;
RX PubMed=19251847; DOI=10.1128/jb.01779-08;
RA Slater S.C., Goldman B.S., Goodner B., Setubal J.C., Farrand S.K.,
RA Nester E.W., Burr T.J., Banta L., Dickerman A.W., Paulsen I., Otten L.,
RA Suen G., Welch R., Almeida N.F., Arnold F., Burton O.T., Du Z., Ewing A.,
RA Godsy E., Heisel S., Houmiel K.L., Jhaveri J., Lu J., Miller N.M.,
RA Norton S., Chen Q., Phoolcharoen W., Ohlin V., Ondrusek D., Pride N.,
RA Stricklin S.L., Sun J., Wheeler C., Wilson L., Zhu H., Wood D.W.;
RT "Genome sequences of three Agrobacterium biovars help elucidate the
RT evolution of multichromosome genomes in bacteria.";
RL J. Bacteriol. 191:2501-2511(2009).
CC -!- FUNCTION: Required for the first step of histidine biosynthesis. May
CC allow the feedback regulation of ATP phosphoribosyltransferase activity
CC by histidine. {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- MISCELLANEOUS: This function is generally fulfilled by the C-terminal
CC part of HisG, which is missing in some bacteria such as this one.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC HisZ subfamily. {ECO:0000255|HAMAP-Rule:MF_00125}.
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DR EMBL; CP000628; ACM25600.1; -; Genomic_DNA.
DR RefSeq; WP_012651006.1; NC_011985.1.
DR AlphaFoldDB; B9J9Y2; -.
DR SMR; B9J9Y2; -.
DR STRING; 311403.Arad_1056; -.
DR EnsemblBacteria; ACM25600; ACM25600; Arad_1056.
DR KEGG; ara:Arad_1056; -.
DR eggNOG; COG3705; Bacteria.
DR HOGENOM; CLU_025113_6_0_5; -.
DR OMA; YYTGFEF; -.
DR OrthoDB; 277998at2; -.
DR UniPathway; UPA00031; UER00006.
DR Proteomes; UP000001600; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.930.10; -; 1.
DR HAMAP; MF_00125; HisZ; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR041715; HisRS-like_core.
DR InterPro; IPR004516; HisRS/HisZ.
DR InterPro; IPR004517; HisZ.
DR PANTHER; PTHR43707; PTHR43707; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR SUPFAM; SSF55681; SSF55681; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis;
KW Reference proteome.
FT CHAIN 1..372
FT /note="ATP phosphoribosyltransferase regulatory subunit"
FT /id="PRO_1000122657"
SQ SEQUENCE 372 AA; 40275 MW; 3CA09EA820FBF973 CRC64;
MPLIDLPDFA GDLIAEFAAR RTDRVDTPII QPAEPFLDMA GEDLRRRIFL TESETGASLC
LRPEFTIPVC LQHIETATGT PKRYSYLGEI FRQRREGGQE FYQAGIEDLG DRDIASADAR
AVGDAIAILN RLVPGKALSV TLGDQAVFEA VVQALGLPSG WQKRLIHAFG NMMQLETLLA
RLASPQPVTG LDPHALDFLT RGDEQGLVMH IDSTMQATGY STNASRSPLE IARRLREKLV
LSETRLDDEA FRVLEEFLSL SVPLADASSA LAGFADAAGL KLGTALERFD ARVAALANAG
VDAGSIDYRA AFGRPLDYYT GLVFEVTMEG SAAVLVGGGR FDRLLTLLGA KDHIPAVGFA
LWLDRIETAR AA