ANTRL_HUMAN
ID ANTRL_HUMAN Reviewed; 631 AA.
AC A6NF34; H3BPS2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 3.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Anthrax toxin receptor-like;
DE Flags: Precursor;
GN Name=ANTXRL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ATR family. {ECO:0000305}.
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DR EMBL; AL450388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL603965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS60524.1; -.
DR RefSeq; NP_001265617.1; NM_001278688.2.
DR AlphaFoldDB; A6NF34; -.
DR SMR; A6NF34; -.
DR STRING; 9606.ENSP00000480615; -.
DR iPTMnet; A6NF34; -.
DR PhosphoSitePlus; A6NF34; -.
DR BioMuta; ANTXRL; -.
DR MassIVE; A6NF34; -.
DR PaxDb; A6NF34; -.
DR PeptideAtlas; A6NF34; -.
DR PRIDE; A6NF34; -.
DR ProteomicsDB; 1025; -.
DR ProteomicsDB; 41578; -.
DR Antibodypedia; 75200; 1 antibodies from 1 providers.
DR DNASU; 195977; -.
DR Ensembl; ENST00000620264.5; ENSP00000480615.1; ENSG00000274209.6.
DR GeneID; 195977; -.
DR KEGG; hsa:195977; -.
DR MANE-Select; ENST00000620264.5; ENSP00000480615.1; NM_001278688.3; NP_001265617.1.
DR UCSC; uc031wet.2; human.
DR CTD; 195977; -.
DR DisGeNET; 195977; -.
DR GeneCards; ANTXRL; -.
DR HGNC; HGNC:27277; ANTXRL.
DR HPA; ENSG00000274209; Tissue enriched (testis).
DR neXtProt; NX_A6NF34; -.
DR OpenTargets; ENSG00000274209; -.
DR VEuPathDB; HostDB:ENSG00000274209; -.
DR eggNOG; ENOG502QSKR; Eukaryota.
DR GeneTree; ENSGT00940000157727; -.
DR InParanoid; A6NF34; -.
DR OMA; DQVICRF; -.
DR OrthoDB; 613698at2759; -.
DR PhylomeDB; A6NF34; -.
DR TreeFam; TF328943; -.
DR PathwayCommons; A6NF34; -.
DR BioGRID-ORCS; 195977; 25 hits in 922 CRISPR screens.
DR GenomeRNAi; 195977; -.
DR Pharos; A6NF34; Tdark.
DR PRO; PR:A6NF34; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; A6NF34; protein.
DR Bgee; ENSG00000274209; Expressed in right testis and 78 other tissues.
DR ExpressionAtlas; A6NF34; baseline and differential.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:1901998; P:toxin transport; IBA:GO_Central.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF05587; Anth_Ig; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Membrane; Metal-binding; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..631
FT /note="Anthrax toxin receptor-like"
FT /id="PRO_0000332166"
FT TOPO_DOM 28..353
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..631
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 76..246
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 382..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..413
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 84
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250"
FT BINDING 86
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250"
FT BINDING 150
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250"
FT VARIANT 550
FT /note="P -> R (in dbSNP:rs1554967247)"
FT /id="VAR_042963"
SQ SEQUENCE 631 AA; 70629 MW; 5C9D12C7E701D784 CRC64;
MGSHESLGPY FLVFLLLLLL PPPLFRAGSL RYHGPDWRIF HRLALGSRRA HHHHGPGWRQ
HWRQGQAGHR CQGSFDLYFI LDKSGSVNNN WIDLYMWVEE TVARFQSPNI RMCFITYSTD
GQTVLPLTSD KNRIKNGLDQ LQKIVPDGHT FMQAGFRKAI QQIESFNSGN KVPSMIIAMT
DGELVAHAFQ DTLREAQKAR KLGANVYTLG VADYNLDQIT AIADSPGHVF AVENGFKALR
STIDALTSKV CLDVTSVEPS SECVGEPYHV VIHGNGFQNL KKRDEVICRF IFNESTIIDE
KPTSIDNNSM NCPGPKLEKP GEEYSIEVSL NKGKTFFKSN VSITSTTCGI FRNWLYFVPL
LLLVPLLLCC VWRLCRKQTV KEPPPVQKPE KEPEQEKPPS PPPPPPPPPP PLPPPPPAPV
NTCPTVIICC CGCQGVGGMR RIEGNLDTFC DLSHASCHQV PWMCCQSRDQ GRYLSLALAQ
SQYAQAPCCP RICFPHSQEC LSLPQAPCSP RMCLRHSREC LALKQARCSP NICLRHSQHS
RECLARKQAP CSPRICLRHS PEYFSQAQTL CNPKSCLQPS RECLPLTCSS RCRLPPARCL
RPPSRMLPLL SPLLRHTAEP PLSLPPSEPN F
