ID   ANTRL_MACFA             Reviewed;         557 AA.
AC   Q4R7B7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Anthrax toxin receptor-like;
DE   Flags: Precursor;
GN   Name=ANTXRL; ORFNames=QtsA-15671;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ATR family. {ECO:0000305}.
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DR   EMBL; AB168903; BAE01005.1; -; mRNA.
DR   AlphaFoldDB; Q4R7B7; -.
DR   SMR; Q4R7B7; -.
DR   STRING; 9541.XP_005565180.1; -.
DR   eggNOG; ENOG502QSKR; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF05587; Anth_Ig; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..557
FT                   /note="Anthrax toxin receptor-like"
FT                   /id="PRO_0000332167"
FT   TOPO_DOM        26..345
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        367..557
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          74..244
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          380..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          497..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..395
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..411
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        497..520
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..557
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         82
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
FT   BINDING         84
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
FT   BINDING         148
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   557 AA;  62019 MW;  B524252DEBE18FAC CRC64;
     MRSHGRWGPC FLLFLLLLPP PLFRAGSLRY HGPGWRMFQR LALGSRRANH HHGPGWRQQL
     RQGQAGHRCQ GSFDLYFILD KSGSVNNNWI DLYMWVEETV ARFQSSDIRM CFITYSTDGQ
     TVLPLTSDKN RIKNGLDQLR KIVPDGHTFM QAGFRKAIQQ IETFNSGNKV PSMIIAMTDG
     ELVAHAFQDT LREAQKARKL GANVYTVDVA DYKLDQITAI ADSPEHVFAV ENGFKAMRDT
     VDALTSKVCL DVTSVEPPTV CVGEPYHVVV HGNGFQNLKK QDEVICRFIF NETTIVDEKP
     TSIDNNSMNC PGPKLEKPGE EYFIEVSLNN GKTFFKSNVS VTSSTCGIFS NWLYFLLPLL
     LLPLLLCCLW RLCRKKTVKE PPPVQKPEKE PEQEKPPPPP PPSPPPPLPP PPPPPPPVNT
     CPTVIVCCCA CQGVCGIRGI EGNLDTFCDL SHPSCCQVPW MWCQRRDQGR YLSLALAQSQ
     YAQAPCCPRI GFPHSQESPS LPETQPGVLF PSTDSVQPKE LPSTWPAVPP HCSGTLQNPL
     CPSLPRSPTS KAPNTQD