HISZ_BRUO2
ID HISZ_BRUO2 Reviewed; 376 AA.
AC A5VTT5;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=ATP phosphoribosyltransferase regulatory subunit {ECO:0000255|HAMAP-Rule:MF_00125};
GN Name=hisZ {ECO:0000255|HAMAP-Rule:MF_00125}; OrderedLocusNames=BOV_A0170;
OS Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=444178;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25840 / 63/290 / NCTC 10512;
RX PubMed=19436743; DOI=10.1371/journal.pone.0005519;
RA Tsolis R.M., Seshadri R., Santos R.L., Sangari F.J., Lobo J.M.,
RA de Jong M.F., Ren Q., Myers G., Brinkac L.M., Nelson W.C., Deboy R.T.,
RA Angiuoli S., Khouri H., Dimitrov G., Robinson J.R., Mulligan S.,
RA Walker R.L., Elzer P.E., Hassan K.A., Paulsen I.T.;
RT "Genome degradation in Brucella ovis corresponds with narrowing of its host
RT range and tissue tropism.";
RL PLoS ONE 4:E5519-E5519(2009).
CC -!- FUNCTION: Required for the first step of histidine biosynthesis. May
CC allow the feedback regulation of ATP phosphoribosyltransferase activity
CC by histidine. {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- MISCELLANEOUS: This function is generally fulfilled by the C-terminal
CC part of HisG, which is missing in some bacteria such as this one.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC HisZ subfamily. {ECO:0000255|HAMAP-Rule:MF_00125}.
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DR EMBL; CP000709; ABQ62267.1; -; Genomic_DNA.
DR RefSeq; WP_002972153.1; NC_009504.1.
DR AlphaFoldDB; A5VTT5; -.
DR SMR; A5VTT5; -.
DR EnsemblBacteria; ABQ62267; ABQ62267; BOV_A0170.
DR GeneID; 45125587; -.
DR KEGG; bov:BOV_A0170; -.
DR HOGENOM; CLU_025113_6_0_5; -.
DR OMA; YYTGFEF; -.
DR UniPathway; UPA00031; UER00006.
DR Proteomes; UP000006383; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.930.10; -; 1.
DR HAMAP; MF_00125; HisZ; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR041715; HisRS-like_core.
DR InterPro; IPR004516; HisRS/HisZ.
DR InterPro; IPR004517; HisZ.
DR PANTHER; PTHR43707; PTHR43707; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR SUPFAM; SSF55681; SSF55681; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis.
FT CHAIN 1..376
FT /note="ATP phosphoribosyltransferase regulatory subunit"
FT /id="PRO_1000095447"
SQ SEQUENCE 376 AA; 40689 MW; 59DF397DB155EC1F CRC64;
MVGSRTSPIF NALRVELNAR EAELVEIPLI QPADPFLDMA GEDLRRRIFL TENENGDSLC
LRPEFTIPVC RNHIALNAAT PKRYAYLGEV FRQRRDGAAE FLQAGIEDLG AADEAASDAR
SLADALSCVK AIAPDAPLEI VLGDQSVFAG MLKALGLPQG WRKKLLRSFG DAHSMDLALA
ELTGTQRRDP LPESLAVLVA EGDEIGLARM LEAEMLEAGI SPGAGRTPVE IARRLIEKED
LAATHFPAAA LDLLRQFLAI RVSLDMAAVT LRAFAADNAL DLGAVLQKFE ARADAIAQAG
IEMKDIIYDA SFGRPLDYYT GLVYEIRDAS NRQDGVLAGG GRYDRLLTML GACEAIPGVG
FSIWLDRLQA LAGEKQ