ANTRL_MOUSE
ID ANTRL_MOUSE Reviewed; 641 AA.
AC Q8BVM2; E9QNF3;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Anthrax toxin receptor-like;
DE Flags: Precursor;
GN Name=Antxrl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ATR family. {ECO:0000305}.
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DR EMBL; AK077206; BAC36683.1; -; mRNA.
DR EMBL; AC164099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS26931.1; -.
DR RefSeq; NP_766396.2; NM_172808.2.
DR AlphaFoldDB; Q8BVM2; -.
DR SMR; Q8BVM2; -.
DR STRING; 10090.ENSMUSP00000052816; -.
DR PhosphoSitePlus; Q8BVM2; -.
DR PaxDb; Q8BVM2; -.
DR PRIDE; Q8BVM2; -.
DR ProteomicsDB; 296317; -.
DR DNASU; 239029; -.
DR Ensembl; ENSMUST00000058725; ENSMUSP00000052816; ENSMUSG00000047441.
DR GeneID; 239029; -.
DR KEGG; mmu:239029; -.
DR UCSC; uc007tai.1; mouse.
DR CTD; 195977; -.
DR MGI; MGI:1925726; Antxrl.
DR VEuPathDB; HostDB:ENSMUSG00000047441; -.
DR eggNOG; ENOG502QSKR; Eukaryota.
DR GeneTree; ENSGT00940000157727; -.
DR HOGENOM; CLU_029760_1_0_1; -.
DR InParanoid; Q8BVM2; -.
DR OMA; DQVICRF; -.
DR OrthoDB; 613698at2759; -.
DR PhylomeDB; Q8BVM2; -.
DR TreeFam; TF328943; -.
DR BioGRID-ORCS; 239029; 2 hits in 70 CRISPR screens.
DR PRO; PR:Q8BVM2; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BVM2; protein.
DR Bgee; ENSMUSG00000047441; Expressed in testis and 13 other tissues.
DR ExpressionAtlas; Q8BVM2; baseline and differential.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:1901998; P:toxin transport; IBA:GO_Central.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF05587; Anth_Ig; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Metal-binding; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..641
FT /note="Anthrax toxin receptor-like"
FT /id="PRO_0000332168"
FT TOPO_DOM 28..363
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 385..641
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 76..247
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 391..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..455
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 84
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250"
FT BINDING 86
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250"
FT BINDING 150
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250"
FT CONFLICT 143
FT /note="N -> S (in Ref. 1; BAC36683)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 641 AA; 70443 MW; 299E3666499817AA CRC64;
MMSHSPSMPC SALFLLLLLL LPPTFKGGSL RYHGPGWKLF HRLSKGFRSS HQRQTQQMRQ
NVPQGQSGDD CQGIFDLYLV LDKSGSVADN WIHIYSFAEG LVKKFTNPNL RISIITYSTE
AEVILPLTSD SKEINKSLLV LKNIVPQGLT HMQKGLRKAN EQIRKSTLGG RIVNSVIIAL
TDGLLLLKPY LDTMEEAKKA RRMGAIVYTV GVFMYSKQQL VNIAGDPDRC FGVDEGFSAL
EGVVDPLTSK SCTEILSVQP TYVCAKDFYQ VNISGHGLNN TSNMKQVICR FKFSDSKVVD
ESPSDMNEHS ITCPGPKIKH TGEDVSLQVS LNNGISFIGN KLIITSTNCW SPRASQGIVF
KRTWLMFLPV LLVTLLLLCC TWKLCIKPKK LPPPPPKPEK EPEEESPPPS SPPAPGRGPG
PGPSAGPGPG PGPSPGSGPA RSPVPARPPP APLPANTNPT VIVACCGCGN RGMQGNLDTC
CDYFHPSCHP MPLVWCHPKA QGGYPGFAVM KPSCSQASCR QKHCLCSNRD CFHLAEPPYP
TRIVFQPNEK YFSITQSHYS PKIRFQTNQE SLPVAQTLCS KMCSPPNQEC YTFKSPQSPY
QARYTKSPAR MLPLLPPHTR QSLESLCHTY PFPPISKGPK F
