ANTR_CHICK
ID ANTR_CHICK Reviewed; 105 AA.
AC P09859;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 3.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Gastrin/cholecystokinin-like peptide;
DE AltName: Full=Antral peptide;
DE Flags: Precursor;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=7607213; DOI=10.1111/j.1432-1033.1995.tb20580.x;
RA Wu S.V., Dimaline R., Walsh J.H., Campbell B.J.;
RT "Molecular characterization and physiological regulation of a TATA-less
RT gene encoding chicken gastrin.";
RL Eur. J. Biochem. 230:439-446(1995).
RN [2]
RP PROTEIN SEQUENCE OF 41-93, SULFATION AT TYR-87, AND AMIDATION AT PHE-93.
RC TISSUE=Gastric antrum;
RX PubMed=1523171; DOI=10.1016/0196-9781(92)90095-k;
RA Bjoernskov I., Rehfeld J.F., Johnsen A.H.;
RT "Identification of four chicken gastrins, obtained by processing at post-
RT Phe bonds.";
RL Peptides 13:595-601(1992).
RN [3]
RP PROTEIN SEQUENCE OF 58-93.
RC TISSUE=Gastric antrum;
RX PubMed=3743781; DOI=10.1016/0014-5793(86)80920-6;
RA Dimaline R., Young J., Gregory H.;
RT "Isolation from chicken antrum, and primary amino acid sequence of a novel
RT 36-residue peptide of the gastrin/CCK family.";
RL FEBS Lett. 205:318-322(1986).
CC -!- FUNCTION: Potent stimulus of gastric acid, but not of pancreatic
CC secretion.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000305}.
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DR EMBL; U25125; AAA65926.1; -; Genomic_DNA.
DR EMBL; U25124; AAA65925.1; -; mRNA.
DR PIR; S65677; S65677.
DR RefSeq; NP_990731.1; NM_205400.1.
DR AlphaFoldDB; P09859; -.
DR STRING; 9031.ENSGALP00000041428; -.
DR GeneID; 396365; -.
DR KEGG; gga:396365; -.
DR VEuPathDB; HostDB:LOC396365; -.
DR eggNOG; ENOG502SA9S; Eukaryota.
DR OrthoDB; 1589970at2759; -.
DR PRO; PR:P09859; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR InterPro; IPR001651; Gastrin/CCK.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR Pfam; PF00918; Gastrin; 1.
DR PROSITE; PS00259; GASTRIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Digestion;
KW Direct protein sequencing; Hormone; Reference proteome; Secreted; Signal;
KW Sulfation.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..38
FT /id="PRO_0000010656"
FT PEPTIDE 41..93
FT /note="Gastrin/cholecystokinin-like peptide"
FT /id="PRO_0000010657"
FT PROPEP 97..105
FT /id="PRO_0000010658"
FT REGION 24..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 87
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000269|PubMed:1523171"
FT MOD_RES 93
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:1523171,
FT ECO:0000269|PubMed:3743781"
SQ SEQUENCE 105 AA; 11625 MW; 9DB4B005EBD931DC CRC64;
MKTKVFLGLI LSAAVTACLC RPAAKAPGGS HRPTSSLARR DWPEPPSQEQ QQRFISRFLP
HVFAELSDRK GFVQGNGAVE ALHDHFYPDW MDFGRRSTED AADAA
