HISZ_CALS4
ID HISZ_CALS4 Reviewed; 379 AA.
AC Q8R880;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=ATP phosphoribosyltransferase regulatory subunit {ECO:0000255|HAMAP-Rule:MF_00125};
GN Name=hisZ {ECO:0000255|HAMAP-Rule:MF_00125}; Synonyms=hisS2;
GN OrderedLocusNames=TTE2140;
OS Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Caldanaerobacter.
OX NCBI_TaxID=273068;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX PubMed=11997336; DOI=10.1101/gr.219302;
RA Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA Wang J., Yu J., Yang H.;
RT "A complete sequence of the T. tengcongensis genome.";
RL Genome Res. 12:689-700(2002).
CC -!- FUNCTION: Required for the first step of histidine biosynthesis. May
CC allow the feedback regulation of ATP phosphoribosyltransferase activity
CC by histidine. {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00125}.
CC -!- MISCELLANEOUS: This function is generally fulfilled by the C-terminal
CC part of HisG, which is missing in some bacteria such as this one.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC HisZ subfamily. {ECO:0000255|HAMAP-Rule:MF_00125}.
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DR EMBL; AE008691; AAM25305.1; -; Genomic_DNA.
DR RefSeq; WP_009610404.1; NC_003869.1.
DR AlphaFoldDB; Q8R880; -.
DR SMR; Q8R880; -.
DR STRING; 273068.TTE2140; -.
DR EnsemblBacteria; AAM25305; AAM25305; TTE2140.
DR KEGG; tte:TTE2140; -.
DR eggNOG; COG3705; Bacteria.
DR HOGENOM; CLU_025113_0_2_9; -.
DR OMA; ELVMPPM; -.
DR OrthoDB; 1236894at2; -.
DR UniPathway; UPA00031; UER00006.
DR Proteomes; UP000000555; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00773; HisRS-like_core; 1.
DR Gene3D; 3.30.930.10; -; 1.
DR HAMAP; MF_00125; HisZ; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR041715; HisRS-like_core.
DR InterPro; IPR004516; HisRS/HisZ.
DR InterPro; IPR004517; HisZ.
DR PANTHER; PTHR43707; PTHR43707; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR SUPFAM; SSF55681; SSF55681; 1.
DR TIGRFAMs; TIGR00443; hisZ_biosyn_reg; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis;
KW Reference proteome.
FT CHAIN 1..379
FT /note="ATP phosphoribosyltransferase regulatory subunit"
FT /id="PRO_0000171074"
SQ SEQUENCE 379 AA; 44209 MW; C9C9FCF1F73CD319 CRC64;
MIYLPDGVQD FLPEEYEFKR NIEDKFREVF KSFGYKEIMP PTFEYSENFS HLFDENSMYR
FFDKKGNILA LRPDVTAQIA RIVSTKLEGR YPLKLCYVAN VYRYEDTQVG KMREFTQAGV
ELIGTNHEES DAEVIALSIE ALKSTGLKDF KIDIGHAEVF GSIVRNLNLG NEDVNLLREL
LEQKNQSAIE DFIKQKEIKR EEAKLLRELP LLFGGEEILE KLKKENFKET EGVLEYLDRV
YKILEDFGMK EYISFDLGMV QNLNYYTGII FRGFVKGLGY AICTGGRYDK LLKIYGKDLP
ATGFAISVER VMLALQRQSK GEWVKPRRVL VRYKEEERRR AYEKANVLRK EGNVVEMYTF
KRCENIDLKS FDEVVDVGE
