ID   ANTR_LITCT              Reviewed;         102 AA.
AC   P80111;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Gastrin/cholecystokinin-like peptide;
DE   AltName: Full=Antral peptide;
DE   Flags: Precursor;
GN   Name=GAST;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=9075736; DOI=10.1210/endo.138.4.5084;
RA   Rourke I.J., Rehfeld J.F., Moeller M., Johnson A.H.;
RT   "Characterization of the cholecystokinin and gastrin genes from the
RT   bullfrog, Rana catesbeiana: evolutionary conservation of primary and
RT   secondary sites of gene expression.";
RL   Endocrinology 138:1719-1727(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 46-92, SULFATION AT TYR-86, AND AMIDATION AT PHE-92.
RC   TISSUE=Gastric mucosa;
RX   PubMed=1633800; DOI=10.1111/j.1432-1033.1992.tb17065.x;
RA   Johnsen A.H., Rehfeld J.F.;
RT   "Identification of cholecystokinin/gastrin peptides in frog and turtle.
RT   Evidence that cholecystokinin is phylogenetically older than gastrin.";
RL   Eur. J. Biochem. 207:419-428(1992).
CC   -!- FUNCTION: May control digestion processes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in antrum, duodenum, colon, pancreas,
CC       brain and testis. No expression found in kidney, lung, liver, skin or
CC       distal two-thirds of small intestine. In the brain, strongly expressed
CC       in the pituitary gland with moderate expression in the neural lobe,
CC       brain stem and hypothalamus.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   EMBL; Y08399; CAA69676.1; -; Genomic_DNA.
DR   EMBL; Y08400; CAA69676.1; JOINED; Genomic_DNA.
DR   EMBL; Y08397; CAA69675.1; -; mRNA.
DR   PIR; S24142; S24142.
DR   AlphaFoldDB; P80111; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   InterPro; IPR039236; GAST.
DR   InterPro; IPR001651; Gastrin/CCK.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PANTHER; PTHR19309; PTHR19309; 1.
DR   Pfam; PF00918; Gastrin; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Digestion;
KW   Direct protein sequencing; Hormone; Secreted; Signal; Sulfation.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..45
FT                   /evidence="ECO:0000269|PubMed:1633800"
FT                   /id="PRO_0000010659"
FT   PEPTIDE         46..92
FT                   /note="Gastrin/cholecystokinin-like peptide"
FT                   /id="PRO_0000010660"
FT   PROPEP          96..102
FT                   /id="PRO_0000010661"
FT   MOD_RES         86
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:1633800"
FT   MOD_RES         92
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:1633800"
SQ   SEQUENCE   102 AA;  11551 MW;  6FCBEB01538A0C93 CRC64;
     MDKKVCVSIL LAMLAIAALC RPMTELESAR HGAQRKNSIS DVSRRDLLAS LTHEQKQLIM
     SQLLPELLSE LSNAEDHLHP MRDRDYAGWM DFGRRSSEVT ES