ID   ANVM_PSEAE              Reviewed;         131 AA.
AC   Q9HXD2;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Anaerobic and virulence modulator AnvM {ECO:0000303|PubMed:31337721};
GN   Name=anvM {ECO:0000303|PubMed:31337721}; OrderedLocusNames=PA3880;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=31337721; DOI=10.1128/mbio.01362-19;
RA   Zhang Y., Zhou C.M., Pu Q., Wu Q., Tan S., Shao X., Zhang W., Xie Y.,
RA   Li R., Yu X.J., Wang R., Zhang L., Wu M., Deng X.;
RT   "Pseudomonas aeruginosa regulatory protein AnvM controls pathogenicity in
RT   anaerobic environments and impacts host defense.";
RL   MBio 10:0-0(2019).
CC   -!- FUNCTION: Plays an essential role by modulating the expression of
CC       hundreds of genes including quorum sensing system genes and oxidative
CC       stress resistance genes under both aerobic and anaerobic conditions.
CC       {ECO:0000269|PubMed:31337721}.
CC   -!- DISRUPTION PHENOTYPE: Deletion decreases host innate immune response.
CC       Diminishes bacterial phagocytosis by host alveolar macrophages.
CC       {ECO:0000269|PubMed:31337721}.
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DR   EMBL; AE004091; AAG07267.1; -; Genomic_DNA.
DR   PIR; G83160; G83160.
DR   RefSeq; NP_252569.1; NC_002516.2.
DR   RefSeq; WP_003092971.1; NZ_QZGE01000001.1.
DR   AlphaFoldDB; Q9HXD2; -.
DR   STRING; 287.DR97_3989; -.
DR   PaxDb; Q9HXD2; -.
DR   PRIDE; Q9HXD2; -.
DR   DNASU; 878665; -.
DR   EnsemblBacteria; AAG07267; AAG07267; PA3880.
DR   GeneID; 878665; -.
DR   KEGG; pae:PA3880; -.
DR   PATRIC; fig|208964.12.peg.4063; -.
DR   PseudoCAP; PA3880; -.
DR   HOGENOM; CLU_143943_1_0_6; -.
DR   InParanoid; Q9HXD2; -.
DR   OMA; RMCCLSA; -.
DR   BioCyc; PAER208964:G1FZ6-3952-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   InterPro; IPR014958; DGC.
DR   Pfam; PF08859; DGC; 1.
DR   PIRSF; PIRSF037181; DGC; 1.
PE   4: Predicted;
KW   Reference proteome; Virulence.
FT   CHAIN           1..131
FT                   /note="Anaerobic and virulence modulator AnvM"
FT                   /id="PRO_0000448534"
SQ   SEQUENCE   131 AA;  14380 MW;  05BE7F38B08949D9 CRC64;
     MMFERSPDDP LPLVYACSGC SNVAQLANDL ALRLDRARLA EMSCIAGVGG DVPLLVRRAR
     SGRPILALDG CPLHCVKGCL ARHEVVPTLH LTLSEHGLKK RYGEDCEAQD AERLFVELER
     LLTPGGKRRC E