ANX10_DROME
ID ANX10_DROME Reviewed; 321 AA.
AC P22465; E1JJR8; E8NH50; Q27586; Q9W5W5;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 19-FEB-2014, sequence version 3.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Annexin B10;
DE AltName: Full=Annexin X;
DE AltName: Full=Annexin-10;
GN Name=AnxB10; Synonyms=AnnX; ORFNames=CG9579;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
RX PubMed=2141610; DOI=10.1016/s0021-9258(19)38604-1;
RA Johnston P.A., Perin M.S., Reynolds G.A., Wasserman S.A., Suedhof T.C.;
RT "Two novel annexins from Drosophila melanogaster. Cloning,
RT characterization, and differential expression in development.";
RL J. Biol. Chem. 265:11382-11388(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7710691; DOI=10.1089/dna.1995.14.349;
RA Benevolenskaya E.V., Nurminsky D.I., Gvozdev V.A.;
RT "Structure of the Drosophila melanogaster annexin X gene.";
RL DNA Cell Biol. 14:349-357(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-320.
RC STRAIN=GT WA;
RA Benevolenskaya E.V., Gvozdev V.A.;
RT "Cluster of tandem repeats in Drosophila genome comprising putative genes
RT encoding cytoplasmic dynein intermediate chain and 3'-part of annexin X.";
RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B;
CC IsoId=P22465-1; Sequence=Displayed;
CC Name=A;
CC IsoId=P22465-2; Sequence=VSP_053652;
CC -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium
CC and phospholipid. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the annexin family. {ECO:0000255|PROSITE-
CC ProRule:PRU01245, ECO:0000305}.
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DR EMBL; M34069; AAA28371.1; -; mRNA.
DR EMBL; X78323; CAA55126.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF45380.1; -; Genomic_DNA.
DR EMBL; AE014298; ACZ95337.1; -; Genomic_DNA.
DR EMBL; AY061328; AAL28876.1; -; mRNA.
DR EMBL; BT125926; ADX35905.1; -; mRNA.
DR EMBL; L41945; AAB51186.1; -; Genomic_DNA.
DR PIR; B42234; LUFF10.
DR RefSeq; NP_001162804.1; NM_001169333.2. [P22465-1]
DR RefSeq; NP_476615.1; NM_057267.4. [P22465-2]
DR AlphaFoldDB; P22465; -.
DR SMR; P22465; -.
DR BioGRID; 59312; 109.
DR IntAct; P22465; 1.
DR STRING; 7227.FBpp0291143; -.
DR TCDB; 1.A.31.1.1; the annexin (annexin) family.
DR PaxDb; P22465; -.
DR PRIDE; P22465; -.
DR DNASU; 33019; -.
DR EnsemblMetazoa; FBtr0070025; FBpp0070024; FBgn0000084. [P22465-2]
DR EnsemblMetazoa; FBtr0301931; FBpp0291143; FBgn0000084. [P22465-1]
DR GeneID; 33019; -.
DR KEGG; dme:Dmel_CG9579; -.
DR CTD; 33019; -.
DR FlyBase; FBgn0000084; AnxB10.
DR VEuPathDB; VectorBase:FBgn0000084; -.
DR eggNOG; KOG0819; Eukaryota.
DR GeneTree; ENSGT00940000165077; -.
DR InParanoid; P22465; -.
DR OMA; CMEGMGT; -.
DR PhylomeDB; P22465; -.
DR Reactome; R-DME-114608; Platelet degranulation.
DR Reactome; R-DME-416476; G alpha (q) signalling events.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR Reactome; R-DME-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR SignaLink; P22465; -.
DR BioGRID-ORCS; 33019; 0 hits in 3 CRISPR screens.
DR ChiTaRS; AnxB10; fly.
DR GenomeRNAi; 33019; -.
DR PRO; PR:P22465; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0000084; Expressed in antenna and 23 other tissues.
DR ExpressionAtlas; P22465; baseline and differential.
DR Genevisible; P22465; DM.
DR GO; GO:0016020; C:membrane; IC:FlyBase.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IDA:FlyBase.
DR Gene3D; 1.10.220.10; -; 4.
DR InterPro; IPR001464; Annexin.
DR InterPro; IPR018502; Annexin_repeat.
DR InterPro; IPR018252; Annexin_repeat_CS.
DR InterPro; IPR037104; Annexin_sf.
DR Pfam; PF00191; Annexin; 4.
DR PRINTS; PR00196; ANNEXIN.
DR SMART; SM00335; ANX; 4.
DR SUPFAM; SSF47874; SSF47874; 1.
DR PROSITE; PS00223; ANNEXIN_1; 1.
DR PROSITE; PS51897; ANNEXIN_2; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Annexin; Calcium; Calcium/phospholipid-binding;
KW Reference proteome; Repeat.
FT CHAIN 1..321
FT /note="Annexin B10"
FT /id="PRO_0000067517"
FT REPEAT 15..86
FT /note="Annexin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REPEAT 87..158
FT /note="Annexin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REPEAT 171..243
FT /note="Annexin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REPEAT 247..319
FT /note="Annexin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT VAR_SEQ 303
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_053652"
FT CONFLICT 216
FT /note="V -> E (in Ref. 7; AAB51186)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="Q -> H (in Ref. 6; ADX35905)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="H -> HD (in Ref. 7; AAB51186)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="R -> Q (in Ref. 7; AAB51186)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 35706 MW; D722C6D872978A02 CRC64;
MEYKPVPTVK DAAPFDASQD AQVLRAAMKG FGTDEQEIID VLVGRSNQQR QTIKAVYEAE
FERDLVDDLK DELGGKFEDV IVGLMMPPVE YLCKQLHAAM AGIGTEEATL VEILCTKTNE
EMAQIVAVYE ERYQRPLAEQ MCSETSGFFR RLLTLIVTGV RDGLDTPVDV GQAKEQAAQL
YSAGEAKLGT DEEVFNRIMS HASFPQLRLV FEEYKVLSGQ TIEQAIKHEM SDELHEAMMA
IVECVQSPAA FFANRLYKAM NGAGTDDATL IRIIVSRSEI DLETIKQEFE RIYNRTLHSA
VVDAETSGDY KRALTALLGS A
