ID   3SOF7_NAJAT             Reviewed;          82 AA.
AC   P49122;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Cytotoxin 7;
DE   AltName: Full=Cardiotoxin-7;
DE            Short=CTX7;
DE            Short=Ctx-7;
DE   AltName: Full=Cardiotoxin-like basic protein 2;
DE            Short=CLBP2;
DE   Flags: Precursor;
OS   Naja atra (Chinese cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=8679666; DOI=10.1016/0167-4838(96)00047-7;
RA   Chang L.-S., Lin J., Wu P.F.;
RT   "cDNA sequence analysis and expression of cardiotoxin V and a new
RT   cardiotoxin VII from Naja naja atra (Taiwan cobra).";
RL   Biochim. Biophys. Acta 1295:1-4(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=15587986; DOI=10.1023/b:bigi.0000043955.35906.c2;
RA   Chang L.-S., Lin S.-K., Chung C.;
RT   "Molecular cloning and evolution of the genes encoding the precursors of
RT   taiwan cobra cardiotoxin and cardiotoxin-like basic protein.";
RL   Biochem. Genet. 42:429-440(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC       residue stands at position 51 (Pro-31 in standard classification).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group XV sub-subfamily. {ECO:0000305}.
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DR   EMBL; Z54231; CAA90967.1; -; mRNA.
DR   EMBL; Y18014; CAA77017.1; -; Genomic_DNA.
DR   PIR; S70375; S70375.
DR   AlphaFoldDB; P49122; -.
DR   SMR; P49122; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003572; Cytotoxin_Cobra.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   PRINTS; PR00282; CYTOTOXIN.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   2: Evidence at transcript level;
KW   Cardiotoxin; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..82
FT                   /note="Cytotoxin 7"
FT                   /id="PRO_0000035382"
FT   DISULFID        24..43
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        36..60
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        64..75
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        76..81
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   82 AA;  9086 MW;  5555DCFF0D974671 CRC64;
     MKTLLLTLVV VTIVCLDLGY TLKCHNTQLP FIYNTCPEGK NLCFKATLKF PLKFPVKRGC
     AATCPRSSSL VKVVCCKTDK CN