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ANX10_HUMAN
ID   ANX10_HUMAN             Reviewed;         324 AA.
AC   Q9UJ72; Q96IQ5; Q9UJV4;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 3.
DT   03-AUG-2022, entry version 166.
DE   RecName: Full=Annexin A10;
DE   AltName: Full=Annexin-10;
DE   AltName: Full=Annexin-14;
GN   Name=ANXA10; Synonyms=ANX14;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT LEU-71.
RC   TISSUE=Lung;
RX   PubMed=10458909; DOI=10.1006/geno.1999.5895;
RA   Morgan R.O., Jenkins N.A., Gilbert D.J., Copeland N.G., Balsara B.R.,
RA   Testa J.R., Fernandez M.-P.;
RT   "Novel human and mouse annexin A10 are linked to the genome duplications
RT   during early chordate evolution.";
RL   Genomics 60:40-49(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Paul H., Gress T.M.;
RT   "Annexin 14 highly expressed in metastatic pancreatic cancer cell line.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9UJ72; P30043: BLVRB; NbExp=5; IntAct=EBI-8648654, EBI-2837485;
CC       Q9UJ72; Q96F86: EDC3; NbExp=11; IntAct=EBI-8648654, EBI-997311;
CC   -!- SIMILARITY: Belongs to the annexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01245, ECO:0000305}.
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DR   EMBL; AJ238979; CAB51917.1; -; mRNA.
DR   EMBL; AF196478; AAF06672.1; -; mRNA.
DR   EMBL; BC007320; AAH07320.1; -; mRNA.
DR   CCDS; CCDS34096.1; -.
DR   RefSeq; NP_009124.2; NM_007193.4.
DR   AlphaFoldDB; Q9UJ72; -.
DR   SMR; Q9UJ72; -.
DR   BioGRID; 116368; 8.
DR   IntAct; Q9UJ72; 2.
DR   MINT; Q9UJ72; -.
DR   STRING; 9606.ENSP00000352248; -.
DR   iPTMnet; Q9UJ72; -.
DR   PhosphoSitePlus; Q9UJ72; -.
DR   BioMuta; ANXA10; -.
DR   DMDM; 126302518; -.
DR   jPOST; Q9UJ72; -.
DR   MassIVE; Q9UJ72; -.
DR   PaxDb; Q9UJ72; -.
DR   PeptideAtlas; Q9UJ72; -.
DR   PRIDE; Q9UJ72; -.
DR   ProteomicsDB; 84595; -.
DR   Antibodypedia; 1612; 468 antibodies from 38 providers.
DR   DNASU; 11199; -.
DR   Ensembl; ENST00000359299.8; ENSP00000352248.3; ENSG00000109511.12.
DR   GeneID; 11199; -.
DR   KEGG; hsa:11199; -.
DR   MANE-Select; ENST00000359299.8; ENSP00000352248.3; NM_007193.5; NP_009124.2.
DR   UCSC; uc003irm.4; human.
DR   CTD; 11199; -.
DR   DisGeNET; 11199; -.
DR   GeneCards; ANXA10; -.
DR   HGNC; HGNC:534; ANXA10.
DR   HPA; ENSG00000109511; Tissue enriched (stomach).
DR   MIM; 608008; gene.
DR   neXtProt; NX_Q9UJ72; -.
DR   OpenTargets; ENSG00000109511; -.
DR   PharmGKB; PA24824; -.
DR   VEuPathDB; HostDB:ENSG00000109511; -.
DR   eggNOG; KOG0819; Eukaryota.
DR   GeneTree; ENSGT00940000160623; -.
DR   HOGENOM; CLU_025300_0_0_1; -.
DR   InParanoid; Q9UJ72; -.
DR   OMA; KEIHDSW; -.
DR   OrthoDB; 856254at2759; -.
DR   PhylomeDB; Q9UJ72; -.
DR   TreeFam; TF105452; -.
DR   PathwayCommons; Q9UJ72; -.
DR   SignaLink; Q9UJ72; -.
DR   BioGRID-ORCS; 11199; 13 hits in 1073 CRISPR screens.
DR   ChiTaRS; ANXA10; human.
DR   GenomeRNAi; 11199; -.
DR   Pharos; Q9UJ72; Tbio.
DR   PRO; PR:Q9UJ72; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q9UJ72; protein.
DR   Bgee; ENSG00000109511; Expressed in pylorus and 102 other tissues.
DR   Genevisible; Q9UJ72; HS.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR001464; Annexin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR018252; Annexin_repeat_CS.
DR   InterPro; IPR037104; Annexin_sf.
DR   InterPro; IPR008156; ANX10.
DR   Pfam; PF00191; Annexin; 4.
DR   PRINTS; PR00196; ANNEXIN.
DR   PRINTS; PR01809; ANNEXINX.
DR   SMART; SM00335; ANX; 4.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS00223; ANNEXIN_1; 1.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   1: Evidence at protein level;
KW   Annexin; Reference proteome; Repeat.
FT   CHAIN           1..324
FT                   /note="Annexin A10"
FT                   /id="PRO_0000067507"
FT   REPEAT          17..88
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          89..160
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          171..243
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          247..318
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   VARIANT         71
FT                   /note="M -> L (in dbSNP:rs6836994)"
FT                   /evidence="ECO:0000269|PubMed:10458909"
FT                   /id="VAR_030786"
FT   CONFLICT        72..85
FT                   /note="REQLSDHFKDVMAG -> KGAAFGSLPRCDGW (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        168
FT                   /note="T -> S (in Ref. 1; CAB51917)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        190
FT                   /note="E -> G (in Ref. 1; CAB51917)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   324 AA;  37278 MW;  DE17DF81B5D8D047 CRC64;
     MFCGDYVQGT IFPAPNFNPI MDAQMLGGAL QGFDCDKDML INILTQRCNA QRMMIAEAYQ
     SMYGRDLIGD MREQLSDHFK DVMAGLMYPP PLYDAHELWH AMKGVGTDEN CLIEILASRT
     NGEIFQMREA YCLQYSNNLQ EDIYSETSGH FRDTLMNLVQ GTREEGYTDP AMAAQDAMVL
     WEACQQKTGE HKTMLQMILC NKSYQQLRLV FQEFQNISGQ DMVDAINECY DGYFQELLVA
     IVLCVRDKPA YFAYRLYSAI HDFGFHNKTV IRILIARSEI DLLTIRKRYK ERYGKSLFHD
     IRNFASGHYK KALLAICAGD AEDY
 
 
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