ID   HISZ_PSEAE              Reviewed;         394 AA.
AC   Q9HUM5;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=ATP phosphoribosyltransferase regulatory subunit;
GN   Name=hisZ; OrderedLocusNames=PA4939;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Required for the first step of histidine biosynthesis. May
CC       allow the feedback regulation of ATP phosphoribosyltransferase activity
CC       by histidine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC   -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: This function is generally fulfilled by the C-terminal
CC       part of HisG, which is missing in some bacteria such as this one.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       HisZ subfamily. {ECO:0000305}.
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DR   EMBL; AE004091; AAG08324.1; -; Genomic_DNA.
DR   PIR; G83027; G83027.
DR   RefSeq; NP_253626.1; NC_002516.2.
DR   RefSeq; WP_003095644.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; Q9HUM5; -.
DR   SMR; Q9HUM5; -.
DR   STRING; 287.DR97_2292; -.
DR   PaxDb; Q9HUM5; -.
DR   PRIDE; Q9HUM5; -.
DR   EnsemblBacteria; AAG08324; AAG08324; PA4939.
DR   GeneID; 877658; -.
DR   KEGG; pae:PA4939; -.
DR   PATRIC; fig|208964.12.peg.5172; -.
DR   PseudoCAP; PA4939; -.
DR   HOGENOM; CLU_025113_0_1_6; -.
DR   InParanoid; Q9HUM5; -.
DR   OMA; ELVMPPM; -.
DR   PhylomeDB; Q9HUM5; -.
DR   BioCyc; PAER208964:G1FZ6-5055-MON; -.
DR   UniPathway; UPA00031; UER00006.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IBA:GO_Central.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   HAMAP; MF_00125; HisZ; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   InterPro; IPR004517; HisZ.
DR   PANTHER; PTHR43707; PTHR43707; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
DR   TIGRFAMs; TIGR00443; hisZ_biosyn_reg; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..394
FT                   /note="ATP phosphoribosyltransferase regulatory subunit"
FT                   /id="PRO_0000171052"
SQ   SEQUENCE   394 AA;  42546 MW;  3CD7832E861723F6 CRC64;
     MATVDRWLLP DGIEEVLPPE AARIEAARRQ VLDLFHRWGY EFVVTPHIEY LESLLTGAGQ
     DLDLRTFKVT DPASGRLMGF RADITPQVAR MDAHSLRREG PSRLCYAGSV LHAQPRALST
     SRSPIQLGAE LYGDPSPASD VEVISLMLEM LEMAEVPDVH MDLGHVGIYR GLARAAGLSG
     EVEQQLFDAL QRKAVDEVEA LTADLPAELR GMLRALAELC GGRDALEQGR ARLAAAPADV
     QVALNELIEI ADSLAGRFPG LPLYFDLGEL RGYHYHTGVV FAAFVPGVGQ SIAQGGRYDD
     IGADFGRARP ATGFSTDLKS LVTLGQARLD QAVSGIWAPA EGAGLWQAVQ RLRRDGQRVV
     QALPGQDAAS AREAGCDRQL ALRDGNWQVA PLAS