ANX11_DROME
ID ANX11_DROME Reviewed; 511 AA.
AC Q9VXG4; M9PEV0; M9PHW3; Q9VXG3;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-FEB-2014, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Annexin B11;
GN Name=AnxB11; ORFNames=CG9968;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RA Fernandez M.-P., Morgan R.O.;
RT "Structural comparison and molecular classification of non-vertebrate
RT animal annexins.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Head, and Ovary;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=B; Synonyms=E, G;
CC IsoId=Q9VXG4-1; Sequence=Displayed;
CC Name=A; Synonyms=C, F;
CC IsoId=Q9VXG4-2; Sequence=VSP_053657;
CC Name=D;
CC IsoId=Q9VXG4-3; Sequence=VSP_053656;
CC -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium
CC and phospholipid. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the annexin family. {ECO:0000255|PROSITE-
CC ProRule:PRU01245, ECO:0000305}.
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DR EMBL; AJ276963; CAB86189.1; -; mRNA.
DR EMBL; AE014298; AAF48609.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF48610.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95456.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95457.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95458.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95459.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95460.1; -; Genomic_DNA.
DR EMBL; AY058397; AAL13626.1; -; mRNA.
DR EMBL; AY122138; AAM52650.1; -; mRNA.
DR EMBL; BT125828; ADR83713.1; -; mRNA.
DR RefSeq; NP_001259614.1; NM_001272685.1. [Q9VXG4-2]
DR RefSeq; NP_001259615.1; NM_001272686.1. [Q9VXG4-3]
DR RefSeq; NP_001259616.1; NM_001272687.1. [Q9VXG4-1]
DR RefSeq; NP_001259617.1; NM_001272688.1. [Q9VXG4-2]
DR RefSeq; NP_001259618.1; NM_001272689.1. [Q9VXG4-1]
DR RefSeq; NP_523370.1; NM_078646.3. [Q9VXG4-2]
DR RefSeq; NP_727978.1; NM_167519.2. [Q9VXG4-1]
DR AlphaFoldDB; Q9VXG4; -.
DR SMR; Q9VXG4; -.
DR BioGRID; 58952; 8.
DR IntAct; Q9VXG4; 3.
DR STRING; 7227.FBpp0306158; -.
DR PaxDb; Q9VXG4; -.
DR PRIDE; Q9VXG4; -.
DR DNASU; 32612; -.
DR EnsemblMetazoa; FBtr0074302; FBpp0074077; FBgn0030749. [Q9VXG4-2]
DR EnsemblMetazoa; FBtr0074303; FBpp0074078; FBgn0030749. [Q9VXG4-1]
DR EnsemblMetazoa; FBtr0334038; FBpp0306154; FBgn0030749. [Q9VXG4-2]
DR EnsemblMetazoa; FBtr0334039; FBpp0306155; FBgn0030749. [Q9VXG4-3]
DR EnsemblMetazoa; FBtr0334040; FBpp0306156; FBgn0030749. [Q9VXG4-1]
DR EnsemblMetazoa; FBtr0334041; FBpp0306157; FBgn0030749. [Q9VXG4-2]
DR EnsemblMetazoa; FBtr0334042; FBpp0306158; FBgn0030749. [Q9VXG4-1]
DR GeneID; 32612; -.
DR KEGG; dme:Dmel_CG9968; -.
DR UCSC; CG9968-RB; d. melanogaster.
DR CTD; 32612; -.
DR FlyBase; FBgn0030749; AnxB11.
DR VEuPathDB; VectorBase:FBgn0030749; -.
DR eggNOG; KOG0819; Eukaryota.
DR GeneTree; ENSGT00940000172288; -.
DR HOGENOM; CLU_025300_6_3_1; -.
DR InParanoid; Q9VXG4; -.
DR OMA; GQMGYPP; -.
DR PhylomeDB; Q9VXG4; -.
DR SignaLink; Q9VXG4; -.
DR BioGRID-ORCS; 32612; 0 hits in 3 CRISPR screens.
DR ChiTaRS; AnxB11; fly.
DR GenomeRNAi; 32612; -.
DR PRO; PR:Q9VXG4; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030749; Expressed in embryonic/larval hemocyte (Drosophila) and 40 other tissues.
DR Genevisible; Q9VXG4; DM.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; ISS:FlyBase.
DR GO; GO:0051592; P:response to calcium ion; ISS:FlyBase.
DR Gene3D; 1.10.220.10; -; 4.
DR InterPro; IPR001464; Annexin.
DR InterPro; IPR018502; Annexin_repeat.
DR InterPro; IPR018252; Annexin_repeat_CS.
DR InterPro; IPR037104; Annexin_sf.
DR Pfam; PF00191; Annexin; 4.
DR PRINTS; PR00196; ANNEXIN.
DR SMART; SM00335; ANX; 4.
DR SUPFAM; SSF47874; SSF47874; 1.
DR PROSITE; PS00223; ANNEXIN_1; 3.
DR PROSITE; PS51897; ANNEXIN_2; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Annexin; Calcium; Calcium/phospholipid-binding;
KW Reference proteome; Repeat.
FT CHAIN 1..511
FT /note="Annexin B11"
FT /id="PRO_0000067518"
FT REPEAT 204..275
FT /note="Annexin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REPEAT 276..347
FT /note="Annexin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REPEAT 359..431
FT /note="Annexin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REPEAT 435..506
FT /note="Annexin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..49
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..216
FT /note="Missing (in isoform D)"
FT /evidence="ECO:0000305"
FT /id="VSP_053656"
FT VAR_SEQ 6..194
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.1"
FT /id="VSP_053657"
SQ SEQUENCE 511 AA; 56215 MW; 74712A8F1C54283B CRC64;
MYPFGSGMPS HPPTSTNHHE PPRAPFGAGW VPPMQQNSPY PPPSQPHPHS QPSSQMHPQQ
HQQYPGGAPA PYPPMSAPYP SAAPSYPPYP TSNPYPAQYA PPAHNHYQQP SVSNSPYPAD
RGYTPAMTAG YDAGYGYGNG QGHGQGHGHG QGHGHGHGQG HEYGHGYGQG YGHGQGHGNG
QGHAHRSLPA HREGTPTVVP AANFDAVKDA HDLRKAMKGF GTDEDALINI ICRRSNEQRQ
EIQRQFKTHF GKDLIEDIKS ETSGNFEKLL VGLLRPIVDY YCAELNDAMA GLGTDEEVLI
EILCTLSNME INTIKNQYLR LYGAHLESEL KSETSGNFKR LLTSLCTAAR DESGRVDPVA
AKNDARELLK AGELRVGTDE SMFNMILCQR NYQQLKLIFQ EYEGMTGHSL EKAIKKEFSG
DVMEGLIAIY RCVTNKAEYF ASRLHKAMAG IGTNDTQLIR VIITRSEIDM TDIKVAFERL
YGKSLKSWIK GDTSGHYKHA LYALVGEQRS S
