ID   HISZ_STAES              Reviewed;         270 AA.
AC   Q8CTV2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=ATP phosphoribosyltransferase regulatory subunit;
GN   Name=hisZ; OrderedLocusNames=SE_0270;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Required for the first step of histidine biosynthesis. May
CC       allow the feedback regulation of ATP phosphoribosyltransferase activity
CC       by histidine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC   -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: This function is generally fulfilled by the C-terminal
CC       part of HisG, which is missing in some bacteria such as this one.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       HisZ subfamily. {ECO:0000305}.
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DR   EMBL; AE015929; AAO03867.1; -; Genomic_DNA.
DR   RefSeq; NP_763825.1; NC_004461.1.
DR   RefSeq; WP_001829417.1; NZ_WBME01000037.1.
DR   AlphaFoldDB; Q8CTV2; -.
DR   SMR; Q8CTV2; -.
DR   STRING; 176280.SE_0270; -.
DR   EnsemblBacteria; AAO03867; AAO03867; SE_0270.
DR   GeneID; 50017664; -.
DR   KEGG; sep:SE_0270; -.
DR   PATRIC; fig|176280.10.peg.248; -.
DR   eggNOG; COG3705; Bacteria.
DR   HOGENOM; CLU_089652_0_0_9; -.
DR   OMA; RYYSNYP; -.
DR   UniPathway; UPA00031; UER00006.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.930.10; -; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR041715; HisRS-like_core.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis.
FT   CHAIN           1..270
FT                   /note="ATP phosphoribosyltransferase regulatory subunit"
FT                   /id="PRO_0000171065"
SQ   SEQUENCE   270 AA;  32171 MW;  EC45CE8C4BB9BD8D CRC64;
     MNNTIISMKE KELRFLKFFH QQKYNVVDFN LIEELDWRRL THEDLQQMDE RSFWQQNKSI
     YALRNDFTDQ LFRYYSNYPT HLKKVAYAGD IIRDNRVIKQ VGIENYEPQF DNITQNFLDF
     QYFIQNVLHD DIQFVILGHY QLIDALLEKN HQTREVMEMI EERNLSGLIQ KLTFNHPIIQ
     ILKENTLNQL KILSHYLPER HPAMVAIQSW AQWFTDHGIT EIHLDVTAQA PRSYYKGIFI
     KCHLKNTTHS VLTGGYYHGS LEGFGLGLTL