ID   3SOFA_NAJAT             Reviewed;          83 AA.
AC   Q91126; O13173; O13230;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Cardiotoxin 7a {ECO:0000312|EMBL:AAB03220.1, ECO:0000312|EMBL:AAB36929.1};
DE   Flags: Precursor;
OS   Naja atra (Chinese cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Chu R.C., Yang C.-C.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has low cytotoxic activity. {ECO:0000250|UniProtKB:P14541}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P62375}. Target
CC       cell membrane {ECO:0000250|UniProtKB:P62375}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC       residue stands at position 52 (Pro-31 in standard classification).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group XV sub-subfamily. {ECO:0000305}.
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DR   EMBL; U58518; AAB03220.1; -; mRNA.
DR   EMBL; U77489; AAB36929.1; -; mRNA.
DR   AlphaFoldDB; Q91126; -.
DR   BMRB; Q91126; -.
DR   SMR; Q91126; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003572; Cytotoxin_Cobra.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   PRINTS; PR00282; CYTOTOXIN.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Secreted; Signal; Target cell membrane;
KW   Target membrane; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..83
FT                   /note="Cardiotoxin 7a"
FT                   /id="PRO_0000035383"
FT   DISULFID        24..43
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        36..61
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        65..76
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        77..82
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   83 AA;  9319 MW;  34D396A474C851DD CRC64;
     MKTLLLTLVV VTIVCLDLGY TLKCHNTQLP FIYKTCPEGK NLCFKATLKK FPLKFPVKRG
     CADNCPKNSA LLKYVCCSTE KCN