HIUH2_CAEEL
ID HIUH2_CAEEL Reviewed; 136 AA.
AC O44578;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Probable 5-hydroxyisourate hydrolase ZK697.8;
DE Short=HIU hydrolase;
DE Short=HIUHase;
DE EC=3.5.2.17;
DE AltName: Full=Transthyretin-like protein ZK697.8;
DE Flags: Precursor;
GN ORFNames=ZK697.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-
CC 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-
CC dihydro-1H-imidazole-5-carboxylate + H(+); Xref=Rhea:RHEA:23736,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18072,
CC ChEBI:CHEBI:58639; EC=3.5.2.17;
CC -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC -!- MISCELLANEOUS: HIU hydrolysis also occurs spontaneously, but more
CC slowly.
CC -!- SIMILARITY: Belongs to the transthyretin family. 5-hydroxyisourate
CC hydrolase subfamily. {ECO:0000305}.
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DR EMBL; FO081798; CCD74369.1; -; Genomic_DNA.
DR PIR; D88957; D88957.
DR RefSeq; NP_503496.2; NM_071095.2.
DR AlphaFoldDB; O44578; -.
DR SMR; O44578; -.
DR STRING; 6239.ZK697.8; -.
DR PaxDb; O44578; -.
DR PeptideAtlas; O44578; -.
DR EnsemblMetazoa; ZK697.8.1; ZK697.8.1; WBGene00022808.
DR GeneID; 191414; -.
DR KEGG; cel:CELE_ZK697.8; -.
DR UCSC; ZK697.8; c. elegans.
DR CTD; 191414; -.
DR WormBase; ZK697.8; CE40007; WBGene00022808; -.
DR eggNOG; KOG3006; Eukaryota.
DR GeneTree; ENSGT00940000153229; -.
DR HOGENOM; CLU_115536_1_0_1; -.
DR InParanoid; O44578; -.
DR OMA; MFRIDNG; -.
DR OrthoDB; 1453185at2759; -.
DR PhylomeDB; O44578; -.
DR Reactome; R-CEL-3000171; Non-integrin membrane-ECM interactions.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-975634; Retinoid metabolism and transport.
DR PRO; PR:O44578; -.
DR Proteomes; UP000001940; Chromosome V.
DR GO; GO:0033971; F:hydroxyisourate hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IBA:GO_Central.
DR CDD; cd05822; TLP_HIUase; 1.
DR Gene3D; 2.60.40.180; -; 1.
DR InterPro; IPR014306; Hydroxyisourate_hydrolase.
DR InterPro; IPR023418; Thyroxine_BS.
DR InterPro; IPR000895; Transthyretin/HIU_hydrolase.
DR InterPro; IPR023416; Transthyretin/HIU_hydrolase_d.
DR InterPro; IPR036817; Transthyretin/HIU_hydrolase_sf.
DR InterPro; IPR023419; Transthyretin_CS.
DR PANTHER; PTHR10395; PTHR10395; 1.
DR Pfam; PF00576; Transthyretin; 1.
DR PRINTS; PR00189; TRNSTHYRETIN.
DR SUPFAM; SSF49472; SSF49472; 1.
DR TIGRFAMs; TIGR02962; hdxy_isourate; 1.
DR PROSITE; PS00768; TRANSTHYRETIN_1; 1.
DR PROSITE; PS00769; TRANSTHYRETIN_2; 1.
PE 3: Inferred from homology;
KW Hydrolase; Purine metabolism; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..136
FT /note="Probable 5-hydroxyisourate hydrolase ZK697.8"
FT /id="PRO_0000050604"
FT BINDING 31
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 69
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 133
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 136 AA; 14978 MW; E07C9DD2B0D2CA60 CRC64;
MIKFLLFLAI AAATVISNAE LAVPTASISA HVLDISGGSP AGGIQILAFI LLNNGWTNIG
SQFTQDNGRV DWVSPDFTLI PGTYRLVYIT EPYYTAKNVE SFYPYVEVVF NIRNATQHYH
VPLTLSPWGY STYRGS
