ID   HJM79_ENTHR             Reviewed;          74 AA.
AC   Q0Z8B6;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Bacteriocin hiracin-JM79;
DE   AltName: Full=Class II sec-dependent bacteriocin {ECO:0000312|EMBL:ABG47453.1};
DE   Flags: Precursor;
GN   Name=hirJM79 {ECO:0000303|PubMed:17326750};
OS   Enterococcus hirae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1354;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABG47453.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 31-72, FUNCTION,
RP   SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   STRAIN=DCH5 {ECO:0000312|EMBL:ABG47453.1};
RX   PubMed=17326750; DOI=10.1111/j.1574-6968.2007.00673.x;
RA   Sanchez J., Diep D.B., Herranz C., Nes I.F., Cintas L.M., Hernandez P.E.;
RT   "Amino acid and nucleotide sequence, adjacent genes, and heterologous
RT   expression of hiracin JM79, a sec-dependent bacteriocin produced by
RT   Enterococcus hirae DCH5, isolated from Mallard ducks (Anas
RT   platyrhynchos).";
RL   FEMS Microbiol. Lett. 270:227-236(2007).
CC   -!- FUNCTION: Bacteriocin with antibacterial activity against the Gram-
CC       positive Listeria, Enterococcus, Propionibacterium, Staphylococcus and
CC       some strains of Clostridium, Lactobacillus and Pediococcus. Lacks
CC       antibacterial activity against Gram-negative bacteria.
CC       {ECO:0000269|PubMed:17326750}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17326750}.
CC   -!- MASS SPECTROMETRY: Mass=5093.7; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17326750};
CC   -!- SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
CC       {ECO:0000255}.
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DR   EMBL; DQ664500; ABG47453.1; -; Genomic_DNA.
DR   RefSeq; WP_002363584.1; NZ_CABEIL010000002.1.
DR   AlphaFoldDB; Q0Z8B6; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   Gene3D; 1.20.5.130; -; 1.
DR   InterPro; IPR002633; Bacteriocin_IIa.
DR   InterPro; IPR023384; Bacteriocin_IIa_CS.
DR   InterPro; IPR023388; Bacteriocin_IIa_dom_sf.
DR   Pfam; PF01721; Bacteriocin_II; 1.
DR   PROSITE; PS60030; BACTERIOCIN_IIA; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000269|PubMed:17326750"
FT   CHAIN           31..74
FT                   /note="Bacteriocin hiracin-JM79"
FT                   /id="PRO_0000352779"
FT   CONFLICT        32
FT                   /note="T -> G (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   74 AA;  8157 MW;  FD9F34EC5CE57211 CRC64;
     MKKKVLKHCV ILGILGTCLA GIGTGIKVDA ATYYGNGLYC NKEKCWVDWN QAKGEIGKII
     VNGWVNHGPW APRR