ID   HK12_MYCTO              Reviewed;         377 AA.
AC   Q7D9K1;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Probable sensor histidine kinase HK;
DE            EC=2.7.13.3;
GN   OrderedLocusNames=MT0630;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Member of the two-component system HK/TcrA. Phosphorylates
CC       TcrA (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- PTM: Autophosphorylated. {ECO:0000305}.
CC   -!- MISCELLANEOUS: HK is composed of two separate proteins (HK1 and HK2)
CC       with a distinct N-terminal sequence in strain ATCC 25618 / H37Rv.
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DR   EMBL; AE000516; AAK44854.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7D9K1; -.
DR   SMR; Q7D9K1; -.
DR   EnsemblBacteria; AAK44854; AAK44854; MT0630.
DR   KEGG; mtc:MT0630; -.
DR   HOGENOM; CLU_733242_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF02518; HATPase_c; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; Transferase;
KW   Two-component regulatory system.
FT   CHAIN           1..377
FT                   /note="Probable sensor histidine kinase HK"
FT                   /id="PRO_0000391081"
FT   DOMAIN          146..350
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   REGION          1..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          346..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..55
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..102
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..164
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..377
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         149
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
SQ   SEQUENCE   377 AA;  41547 MW;  641BC77D6F31378E CRC64;
     MAHPMATHPR LQRRHGARSG SSRCRHRRPV PRRRSRSRPR WRAARAHRRH HRRSGPGIGD
     HPADRARHRR GGRLPAQPRR AAARRPDPRG GANTDHHAAP RHRRAAAGTS HRRRDRLASN
     DSQHHAHPTA TGPRPRTTVR RRRQPRITHP VGTADHRTRT ALRRPRPADQ LSAALRSALE
     ETRRLSGLAD QLLTLARADR PESHPSAKAV PITPLLHESV ARFAATGADI TTRAEPDLFV
     SIDPDHLRRI LTAVLDNAIT HGDGEIAVTA HARDGAVDIG VRDHGPGFAD HFLPVAFDRF
     TRADTARGGR GSGLGLAIVA ALTTTHGGHA NATNHPDGGA ELRITLPTPR PPFHEELPRI
     TSSDTKDPNR EHDTSDQ