ID   HK1_MYCTU               Reviewed;         168 AA.
AC   O07778; L0T5V1;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 3.
DT   25-MAY-2022, entry version 137.
DE   RecName: Full=Sensor histidine kinase component HK1;
DE            EC=2.7.13.3;
GN   OrderedLocusNames=Rv0600c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, ATP-BINDING, CATALYTIC ACTIVITY, AND BIOPHYSICOCHEMICAL
RP   PROPERTIES.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=17434492; DOI=10.1016/j.febslet.2007.03.089;
RA   Shrivastava R., Ghosh A.K., Das A.K.;
RT   "Probing the nucleotide binding and phosphorylation by the histidine kinase
RT   of a novel three-protein two-component system from Mycobacterium
RT   tuberculosis.";
RL   FEBS Lett. 581:1903-1909(2007).
RN   [3]
RP   INTERACTION WITH HK2.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=19246748; DOI=10.1099/mic.0.019059-0;
RA   Shrivastava R., Ghosh A.K., Das A.K.;
RT   "Intra- and intermolecular domain interactions among novel two-component
RT   system proteins coded by Rv0600c, Rv0601c and Rv0602c of Mycobacterium
RT   tuberculosis.";
RL   Microbiology 155:772-779(2009).
CC   -!- FUNCTION: Member of the three-protein two-component system
CC       HK1/HK2/TcrA. Kinase that binds ATP and catalyzes the transfer of a
CC       phosphoryl group from ATP to HK2. {ECO:0000269|PubMed:17434492}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000269|PubMed:17434492};
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Kinetic parameters:
CC         KM=5.75 mM for ATP {ECO:0000269|PubMed:17434492};
CC   -!- SUBUNIT: Interacts with HK2. {ECO:0000269|PubMed:19246748}.
CC   -!- MISCELLANEOUS: HK1 and HK2 are merged into a single protein with a
CC       distinct N-terminal sequence in strain CDC 1551 / Oshkosh.
CC   -!- CAUTION: HK1 and HK2 are incomplete as individual proteins but can
CC       complement each other's function. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43339.1; -; Genomic_DNA.
DR   PIR; C70909; C70909.
DR   RefSeq; NP_215114.2; NC_000962.3.
DR   RefSeq; WP_003900973.1; NZ_NVQJ01000033.1.
DR   AlphaFoldDB; O07778; -.
DR   SMR; O07778; -.
DR   IntAct; O07778; 1.
DR   MINT; O07778; -.
DR   STRING; 83332.Rv0600c; -.
DR   PaxDb; O07778; -.
DR   DNASU; 887847; -.
DR   GeneID; 45424568; -.
DR   GeneID; 887847; -.
DR   KEGG; mtu:Rv0600c; -.
DR   TubercuList; Rv0600c; -.
DR   eggNOG; COG2205; Bacteria.
DR   OMA; PGLAICK; -.
DR   PhylomeDB; O07778; -.
DR   SABIO-RK; O07778; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IDA:MTBBASE.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IDA:MTBBASE.
DR   GO; GO:0070298; P:negative regulation of phosphorelay signal transduction system; IDA:MTBBASE.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF02518; HATPase_c; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase;
KW   Two-component regulatory system.
FT   CHAIN           1..168
FT                   /note="Sensor histidine kinase component HK1"
FT                   /id="PRO_0000391079"
FT   DOMAIN          1..141
FT                   /note="Histidine kinase; second part"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   REGION          137..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   168 AA;  17854 MW;  FE299CAFE5204F04 CRC64;
     MPITPLLHES VARFAATGAD ITTRAEPDLF VSIDPDHLRR ILTAVLDNAI THGDGEIAVT
     AHARDGAVDI GVRDHGPGFA DHFLPVAFDR FTRADTARGG RGSGLGLAIV AALTTTHGGH
     ANATNHPDGG AELRITLPTP RPPFHEELPR ITSSDTKDPN REHDTSDQ