ID   HKS_HELSS               Reviewed;          10 AA.
AC   P86446;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   26-FEB-2020, entry version 14.
DE   RecName: Full=Helokinestatin-1;
OS   Heloderma suspectum suspectum (Reticulate Gila monster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Neoanguimorpha; Helodermatidae; Heloderma.
OX   NCBI_TaxID=709964;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000269|PubMed:18078686};
RX   PubMed=18078686; DOI=10.1016/j.peptides.2007.10.025;
RA   Kwok H.F., Chen T., O'Rourke M., Ivanyi C., Hirst D., Shaw C.;
RT   "Helokinestatin: a new bradykinin B2 receptor antagonist decapeptide from
RT   lizard venom.";
RL   Peptides 29:65-72(2008).
CC   -!- FUNCTION: Helokinestatin antagonizes the vasodilatory actions of
CC       bradykinin at the B2 bradykinin receptor (BDKRB2) in a dose-dependent
CC       manner. {ECO:0000269|PubMed:18078686}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18078686}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:18078686}.
CC   -!- MASS SPECTROMETRY: Mass=1122.62; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:18078686};
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Bradykinin receptor impairing toxin; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Secreted; Toxin; Vasoactive.
FT   PEPTIDE         1..10
FT                   /note="Helokinestatin-1"
FT                   /id="PRO_0000392452"
FT   UNSURE          7
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:18078686"
SQ   SEQUENCE   10 AA;  1123 MW;  3150E9C73776CB47 CRC64;
     GPPYQPLVPR